Citation Select	RENOVE Investigators; Couturaud F, Schmidt J, Sanchez O, Ballerie A, Sevestre MA, Meneveau N, Bertoletti L, Connault J, Benhamou Y, Constans J, Quemeneur T, Lapébie FX, Pernod G, Picart G, Elias A, Doutrelon C, Neveux C, Khider L, Roy PM, Zuily S, Falvo N, Lacroix P, Emmerich J, Mahé I, Boileau J, Yaici A, Le Jeune S, Stéphan D, Plissonneau-Duquene P, Ray V, des Déserts MD, Belhadj-Chaidi R, Lamia B, Gruel Y, Presles E, Girard P, Tromeur C, Moustafa F, Rothstein V, Lacut K, Melac S, Barillot S, Mismetti P, Laporte S, Mottier D, Meyer G, Leroyer C Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial Lancet. 2025 Mar 1;405(10480):725-735. doi: 10.1016/S0140-6736(24)02842-3
Citation Select	CANVAS Investigators; Schrag D, Uno H, Rosovsky R, Rutherford C, Sanfilippo K, Villano JL, Drescher M, Jayaram N, Holmes C, Feldman L, Zattra O, Farrar-Muir H, Cronin C, Basch E, Weiss A, Connors JM Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial JAMA. 2023 Jun 2. doi: 10.1001/jama.2023.7843. Epub ahead of print
Citation Select	CASSINI Investigators; Khorana AA, Soff GA, Kakkar AK, Vadhan-Raj S, Riess H, Wun T, Streiff MB, Garcia DA, Liebman HA, Belani CP, O'Reilly EM, Patel JN, Yimer HA, Wildgoose P, Burton P, Vijapurkar U, Kaul S, Eikelboom J, McBane R, Bauer KA, Kuderer NM, Lyman GH Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer. N Engl J Med. 2019 Feb 21;380(8):720-728. doi: 10.1056/NEJMoa1814630
Citation Select	AVERT Investigators; Carrier M, Abou-Nassar K, Mallick R, Tagalakis V, Shivakumar S, Schattner A, Kuruvilla P, Hill D, Spadafora S, Marquis K, Trinkaus M, Tomiak A, Lee AYY, Gross PL, Lazo-Langner A, El-Maraghi R, Goss G, Le Gal G, Stewart D, Ramsay T, Rodger M, Witham D, Wells PS Apixaban to Prevent Venous Thromboembolism in Patients with Cancer N Engl J Med. 2019 Feb 21;380(8):711-719. doi: 10.1056/NEJMoa1814468.
Citation Select	Vanni S, Becattini C, Nazerian P, Bova C, Stefanone VT, Cimini LA, Viviani G, Caviglioli C, Sanna M, Pepe G, Grifoni S Early discharge of patients with pulmonary embolism in daily clinical practice: A prospective observational study comparing clinical gestalt and clinical rules Thromb Res. 2018 Jul;167:37-43. doi: 10.1016/j.thromres.2018.05.008
Citation Select	Hokusai VTE Cancer Investigators; Raskob GE, van Es N, Verhamme P, Carrier M, Di Nisio M, Garcia D, Grosso MA, Kakkar AK, Kovacs MJ, Mercuri MF, Meyer G, Segers A, Shi M, Wang TF, Yeo E, Zhang G, Zwicker JI, Weitz JI, Büller HR Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism N Engl J Med. 2018 02 15;378(7):615-624
Citation Select	Sachdeva A, Dalton M, Amaragiri SV, Lees T Graduated compression stockings for prevention of deep vein thrombosis Cochrane Database Syst Rev. 2014 Dec 17;(12):CD001484
Citation Select	Akl EA, Kahale L, Barba M, Neumann I, Labedi N, Terrenato I, Sperati F, Muti P, Schünemann H Anticoagulation for the long-term treatment of venous thromboembolism in patients with cancer Cochrane Database Syst Rev. 2014 Jul 8;7:CD006650
Citation Select	Agnelli G, Buller HR, Cohen A, Curto M, Gallus AS, Johnson M, Masiukiewicz U, Pak R, Thompson J, Raskob GE, Weitz JI, AMPLIFY Investigators AMPLIFY Investigators, Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med. 2013 Aug 29;369(9):799-808
Citation Select	PLIFY-EXT Investigators, Agnelli G, Buller HR, Cohen A, Curto M, Gallus AS, Johnson M, Porcari A, Raskob GE, Weitz JI Apixaban for extended treatment of venous thromboembolism N Engl J Med. 2013 Feb 21;368(8):699-708
Citation Select	EINSTEIN–PE Investigators, Büller HR, Prins MH, Lensin AW, Decousus H, Jacobson BF, Minar E, Chlumsky J, Verhamme P, Wells P, Agnelli G, Cohen A, Berkowitz SD, Bounameaux H, Davidson BL, Misselwitz F, Gallus AS, Raskob GE, Schellong S, Segers A Oral rivaroxaban for the treatment of symptomatic pulmonary embolism N Engl J Med. 2012 Apr 5;366(14):1287-97
Citation Select	the ADOPT Trial Investigators, Goldhaber SZ, Leizorovicz A, Kakkar AK, Haas SK, Merli G, Knabb RM, Weitz JI Apixaban versus Enoxaparin for Thromboprophylaxis in Medically Ill Patients N Engl J Med. 2011 Dec 8;365(23):2167-77. Epub 2011 Nov 13
Citation Select	EINSTEIN Investigators, Bauersachs R, Berkowitz SD, Brenner B, Buller HR, Decousus H, Gallus AS, Lensing AW, Misselwitz F, Prins MH, Raskob GE, Segers A, Verhamme P, Wells P, Agnelli G, Bounameaux H, Cohen A, Davidson BL, Piovella F, Schellong S Oral rivaroxaban for symptomatic venous thromboembolism N Engl J Med. 2010 Dec 23;363(26):2499-510
Citation Select	CALISTO Study Group, Decousus H, Prandoni P, Mismetti P, Bauersachs RM, Boda Z, Brenner B, Laporte S, Matyas L, Middeldorp S, Sokurenko G, Leizorovicz A Fondaparinux for the treatment of superficial-vein thrombosis in the legs N Engl J Med. 2010 Sep 23;363(13):1222-32
Citation Select	RE-COVER Study Group, Schulman S, Kearon C, Kakkar AK, Mismetti P, Schellong S, Eriksson H, Baanstra D, Schnee J, Goldhaber SZ Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med. 2009 Dec 10;361(24):2342-52
Citation Select	Lega JC, Lacasse Y, Lakhal L, Provencher S, Natriuretic peptides and troponins in pulmonary embolism: a meta-analysis. Thorax. 2009 Oct;64(10):869-75
Citation Select	Aissaoui N, Martins E, Mouly S, Weber S, Meune C A meta-analysis of bed rest versus early ambulation in the management of pulmonary embolism, deep vein thrombosis, or both Int J Cardiol. 2009 Sep 11;137(1):37-41
Citation Select	Verhovsek M, Douketis JD, Yi Q, Shrivastava S, Tait RC, Baglin T, Poli D, Lim W, Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism. Ann Intern Med. 2008 Oct 7;149(7):481-90, W94
Citation Select	Ageno W, Becattini C, Brighton T, Selby R, Kamphuisen PW Cardiovascular risk factors and venous thromboembolism: a meta-analysis Circulation. 2008 Jan 1;117(1):93-102. Epub 2007 Dec 17
Citation Select	Shorr AF, Jackson WL, Sherner JH, Moores LK Differences between low-molecular-weight and unfractionated heparin for venous thromboembolism prevention following ischemic stroke: a metaanalysis Chest. 2008 Jan;133(1):149-55
Citation Select	Anderson DR, Kahn SR, Rodger MA, Kovacs MJ, Morris T, Hirsch A, Lang E, Stiell I, Kovacs G, Dreyer J, Dennie C, Cartier Y, Barnes D, Burton E, Pleasance S, Skedgel C, O,Rouke K, Wells PS, Computed tomographic pulmonary angiography vs ventilation-perfusion lung scanning in patients with suspected pulmonary embolism: a randomized controlled trial. JAMA. 2007 Dec 19;298(23):2743-53
Citation Select	Becattini C, Vedovati MC, Agnelli G Prognostic value of troponins in acute pulmonary embolism: a meta-analysis. Circulation. 2007 Jul 24;116(4):427-33. Epub 2007 Jul 2
Citation Select	Segal JB, Streiff MB, Hoffman LV, Thornton K, Bass EB, Management of venous thromboembolism: a systematic review for a practice guideline. Ann Intern Med. 2007 Feb 6;146(3):211-22
Citation Select	LITE Trial Investigators; Hull RD, Pineo GF, Brant RF, Mah AF, Burke N, Dear R, Wong T, Cook R, Solymoss S, Poon MC, Raskob G Self-managed long-term low-molecular-weight heparin therapy: the balance of benefits and harms. Am J Med. 2007 Jan;120(1):72-82
Citation Select	Association pour la Promotion de l,Angiologie Hospitalière, Labarere J, Bosson JL, Sevestre MA, Delmas AS, Dupas S, Thenault MH, Legagneux A, Boge G, Terriat B, Pernod G Brief report: graduated compression stocking thromboprophylaxis for elderly inpatients: a propensity analysis J Gen Intern Med. 2006 Dec;21(12):1282-7
Citation Select	PROLONG Investigators; Palareti G, Cosmi B, Legnani C, Tosetto A, Brusi C, Iorio A, Pengo V, Ghirarduzzi A, Pattacini C, Testa S, Lensing AW, Tripodi A D-dimer testing to determine the duration of anticoagulation therapy N Engl J Med. 2006 Oct 26;355(17):1780-9
Citation Select	Canadian Pulmonary Embolism Diagnosis Study (CANPEDS) Group; Kearon C, Ginsberg JS, Douketis J, Turpie AG, Bates SM, Lee AY, Crowther MA, Weitz JI, Brill-Edwards P, Wells P, Anderson DR, Kovacs MJ, Linkins LA, Julian JA, Bonilla LR, Gent M An evaluation of D-dimer in the diagnosis of pulmonary embolism: a randomized trial Ann Intern Med. 2006 Jun 6;144(11):812-21
Citation Select	Lederle FA, Sacks JM, Fiore L, Landefeld CS, Steinberg N, Peters RW, Eid AA, Sebastian J, Stasek JE Jr, Fye CL The prophylaxis of medical patients for thromboembolism pilot study Am J Med. 2006 Jan;119(1):54-9
Citation Select	Aujesky D, Smith KJ, Cornuz J, Roberts MS Cost-effectiveness of low-molecular-weight heparin for treatment of pulmonary embolism Chest. 2005 Sep;128(3):1601-10
Citation Select	Goodacre S, Sutton AJ, Sampson FC Meta-analysis: The value of clinical assessment in the diagnosis of deep venous thrombosis Ann Intern Med. 2005 Jul 19;143(2):129-39
Citation Select	Roy PM, Colombet I, Durieux P, Chatellier G, Sors H, Meyer G Systematic review and meta-analysis of strategies for the diagnosis of suspected pulmonary embolism BMJ. 2005 Jul 30;331(7511):259
Citation Select	Christiansen SC, Cannegieter SC, Koster T, Vandenbroucke JP, Rosendaal FR Thrombophilia, clinical factors, and recurrent venous thrombotic events JAMA. 2005 May 18;293(19):2352-61
Citation Select	Hayashino Y, Goto M, Noguchi Y, Fukui T Ventilation-perfusion scanning and helical CT in suspected pulmonary embolism: meta-analysis of diagnostic performance Radiology. 2005 Mar;234(3):740-8
Citation Select	Dongen C, Belt A, Prins M, Lensing A Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism Cochrane Database Syst Rev. 2004 Oct 18;(4):CD001100
Citation Select	Thromboembolic Pulmonary Hypertension Study Group; Pengo V, Lensing AW, Prins MH, Marchiori A, Davidson BL, Tiozzo F, Albanese P, Biasiolo A, Pegoraro C, Iliceto S, Prandoni P Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism N Engl J Med. 2004 May 27;350(22):2257-64
Citation Select	Gatt ME, Paltiel O, Bursztyn M Is prolonged immobilization a risk factor for symptomatic venous thromboembolism in elderly bedridden patients? Results of a historical-cohort study Thromb Haemost. 2004 Mar;91(3):538-43
Citation Select	Eichinger S, Minar E, Bialonczyk C, Hirschl M, Quehenberger P, Schneider B, Weltermann A, Wagner O, Kyrle PA D-dimer levels and risk of recurrent venous thromboembolism JAMA. 2003 Aug 27;290(8):1071-4
Citation Select	Randomized Comparison of Low-Molecular-Weight Heparin versus Oral Anticoagulant Therapy for the Prevention of Recurrent Venous Thromboembolism in Patients with Cancer (CLOT) Investigators; Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer N Engl J Med. 2003 Jul 10;349(2):146-53
Citation Select	PREVENT Investigators; Ridker PM, Goldhaber SZ, Danielson E, Rosenberg Y, Eby CS, Deitcher SR, Cushman M, Moll S, Kessler CM, Elliott CG, Paulson R, Wong T, Bauer KA, Schwartz BA, Miletich JP, Bounameaux H, Glynn RJ Long-Term, Low-Intensity Warfarin Therapy for the Prevention of Recurrent Venous Thromboembolism N Engl J Med. 2003 Apr 10;348(15):1425-1434
Citation Select	Konstantinides S, Geibel A, Heusel G, Heinrich F, Kasper W; Management Strategies and Prognosis of Pulmonary Embolism-3 Trial Investigators Heparin plus alteplase compared with heparin alone in patients with submassive pulmonary embolism N Engl J Med. 2002 Oct 10;347(15):1143-50
Citation Select	Agnelli G, Prandoni P, Santamaria MG, Bagatella P, Iorio A, Bazzan M, Moia M, Guazzaloca G, Bertoldi A, Tomasi C, Scannapieco G, Ageno W Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis. Warfarin Optimal Duration Italian Trial Investigators N Engl J Med. 2001 Jul 19;345(3):165-9
Citation Select	Perrier A, Howarth N, Didier D, Loubeyre P, Unger PF, de Moerloose P, Slosman D, Junod A, Bounameaux H Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism Ann Intern Med. 2001 Jul 17;135(2):88-97
Citation Select	Pinede L, Ninet J, Duhaut P, Chabaud S, Demolombe-Rague S, Durieu I, Nony P, Sanson C, Boissel JP; Investigators of the "Duree Optimale du Traitement AntiVitamines K" (DOTAVK) Study Comparison of 3 and 6 months of oral anticoagulant therapy after a first episode of proximal deep vein thrombosis or pulmonary embolism and comparison of 6 and 12 weeks of therapy after isolated calf deep vein thrombosis Circulation. 2001 May 22;103(20):2453-60
Citation Select	C. Gregory Elliott; Samuel Z. Goldhaber; Luigi Visani and Marisa DeRosa Chest Radiographs in Acute Pulmonary Embolism. Results From the International Cooperative Pulmonary Embolism Registry Chest. 2000 July;118(1):33-38
Citation Select	Sam Schulman, Per Lindmarker, for the Duration of Anticoagulation Trial. Incidence of Cancer after Prophylaxis with Warfarin against Recurrent Venous Thromboembolism N Engl J Med. 2000 Jun 29;342(26):1953-8
Citation Select	Mullins MD, Becker DM, Hagspiel KD, Philbrick JT The role of spiral volumetric computed tomography in the diagnosis of pulmonary embolism Arch Intern Med. 2000 Feb 14;160(3):293-8
Citation Select	Hull RD, Raskob GE, Brant RF, Pineo GF, Elliott G, Stein PD, Gottschalk A, Valentine KA, Mah AF Low-molecular-weight heparin vs heparin in the treatment of patients with pulmonary embolism. American-Canadian Thrombosis Study Group Arch Intern Med. 2000 Jan 24;160(2):229-36
Citation Select	Samama MM, Cohen AT, Darmon JY, Desjardins L, Eldor A, Janbon C, Leizorovicz A, Nguyen H, Olsson CG, Turpie AG, Weisslinger N A Comparison of Enoxaparin with Placebo for the Prevention of Venous Thromboembolism in Acutely Ill Medical Patients. Prophylaxis in Medical Patients with Enoxaparin Study Group N Engl J Med. 1999 Sep 9;341(11):793-800
Citation Select	Gould MK, Dembitzer AD, Sanders GD, Garber AM Low-Molecular-Weight Heparins Compared with Unfractionated Heparin for Treatment of Acute Deep Venous Thrombosis. A Cost-Effectiveness Analysis Ann Intern Med. 1999 May 18;130(10):789-99
Citation Select	Serra-Prat M, Jovell AJ, Aymerich M [Efficacy and safety of thrombolytic therapy in pulmonary embolism: meta-analysis of randomized controlled trials] [Article in Spanish] Med Clin (Barc). 1999 May 22;112(18):685-9
Citation Select	Goldhaber SZ, Visani L, De Rosa M Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry Lancet. 1999 Apr 24;353(9162):1386-9
Citation Select	Miniati M, Prediletto R, Formichi B, Marini C, Di Ricco G, Tonelli L, Allescia G, Pistolesi M Accuracy of clinical assessment in the diagnosis of pulmonary embolism Am J Respir Crit Care Med. 1999 Mar;159(3):864-71
Citation Select	Ribeiro A, Lindmarker P, Johnsson H, Juhlin-Dannfelt A, Jorfeldt L Pulmonary embolism: one-year follow-up with echocardiography doppler and five-year survival analysis Circulation. 1999 Mar 16;99(10):1325-30
Citation Select	Kearon C, Gent M, Hirsh J, Weitz J, Kovacs MJ, Anderson DR, Turpie AG, Green D, Ginsberg JS, Wells P, MacKinnon B, Julian JA A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism N Engl J Med. 1999 Mar 25;340(12):901-7
Citation Select	Perrier A, Desmarais S, Miron MJ, de Moerloose P, Lepage R, Slosman D, Didier D, Unger PF, Patenaude JV, Bounameaux H. Non-invasive diagnosis of venous thromboembolism in outpatients. Lancet. 1999 Jan 16;353(9148):190-5
Citation Select	Bernardi E, Prandoni P, Lensing A, Agnelli G, Guazzaloca G, Piovella F, Tomasi C, Moia M, Scarano L, Girolami A; the Multicentre Italian D-dimer Ultrasound Study Investigators Group D-dimer testing as an adjunct to ultrasonography in patients with clinically suspected deep vein thrombosis: prospective cohort study BMJ. 1998 Oct 17;317:1037-1040
Citation Select	The Columbus Investigators Low-molecular-weight heparin in the treatment of patients with venous thromboembolism N Engl J Med. 1997 Sep 4;337(10):657-62
Citation Select	Simonneau G, Sors H, Charbonnier B, Page Y, Laaban JP, Azarian R, Laurent M, Hirsch JL, Ferrari E, Bosson JL, Mottier D, Beau B A comparison of low-molecular-weight heparin with unfractionated heparin for acute pulmonary embolism. The THESEE Study Group. Tinzaparine ou Heparine Standard: Evaluations dans l'Embolie Pulmonaire N Engl J Med. 1997 Sep 4;337(10):663-669
Citation Select	Perrier A, Desmarais S, Goehring C, de Moerloose P, Morabia A, Unger PF, Slosman D, Junod A, Bounameaux H D-dimer testing for suspected pulmonary embolism in outpatients Am J Respir Crit Care Med. 1997 Aug;156(2 Pt 1):492-496
Citation Select	Turkstra F, Kuijer PM, van Beek EJ, Brandjes DP, ten Cate JW, Buller HR Diagnostic utility of ultrasonography of leg veins in patients suspected of having pulmonary embolism Ann Intern Med. 1997 May 15;126(10):775-781
Citation Select	Schulman S, Granqvist S, Holmstrom M, Carlsson A, Lindmarker P, Nicol P, Eklund SG, Nordlander S, Larfars G, Leijd B, Linder O, Loogna E The duration of oral anticoagulant therapy after a second episode of venous thromboembolism. The Duration of Anticoagulation Trial Study Group N Engl J Med. 1997 Feb 6;336(6):393-8
Citation Select	Miniati M, Pistolesi M, Marini C, Di Ricco G, Formichi B, Prediletto R, Allescia G, Tonelli L, Sostman HD, Giuntini C Value of perfusion lung scan in the diagnosis of pulmonary embolism: results of the Prospective Investigative Study of Acute Pulmonary Embolism Diagnosis (PISA-PED) Am J Respir Crit Care Med. 1996 Nov;154(5):1387-1393
Citation Select	Prandoni P, Lensing AW, Cogo A, Cuppini S, Villalta S, Carta M, Cattelan AM, Polistena P, Bernardi E, Prins MH The long-term course of acute deep venous thrombosis Ann Intern Med. 1996 Jul 1;125(1):1-7
Citation Select	Stein PD, Goldhaber SZ, Henry JW, Miller AC Arterial blood gas analysis in the assessment of suspected acute pulmonary embolism Chest. 1996 Jan;109(1):78-81
Citation Select	Leizorovicz A, Simonneau G, Decousus H, Boissel JP Comparison of efficacy and safety of low molecular weight heparins and unfractionated heparin in initial treatment of deep venous thrombosis: a meta-analysis BMJ. 1994 Jul 30;309(6950):299-304
Citation Select	The PIOPED Investigators Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED) JAMA. 1990 May 23;263(20):2753-2759