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DIGIT-HF Study Group; Bavendiek U, Großhennig A, Schwab J, Berliner D, Rieth A, Maier LS, Gaspar T, Thomas NH, Liu X, Schallhorn S, Angelini E, Soltani S, Rathje F, Sandu MA, Geller W, Hambrecht R, Zdravkovic M, Philipp S, Kosevic D, Nickenig G, Scheiber D, Winkler S, Becher PM, Lurz P, Hülsmann M, Wiesner S, Schröder C, Neuhaus B, Seltmann A, von der Leyen H, Veltmann C, Störk S, Böhm M, Koch A, Bauersachs J
Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction
N Engl J Med. 2025 Aug 29. doi: 10.1056/NEJMoa2415471
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Baudry G, Pereira O, Roubille F, Villaceque M, Damy T, Duarte K, Tangre P, Girerd N
Cardiologist follow-up and improved outcomes of heart failure: a French nationwide cohort
Eur Heart J. 2025 May 18:ehaf218. doi: 10.1093/eurheartj/ehaf218. Epub ahead of print
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Anker SD, Friede T, Butler J, Talha KM, Placzek M, Diek M, Nosko A, Stas A, Kluge S, Jarczak D, deHeer G, Rybczynski M, Bayés-Genís A, Böhm M, Coats AJS, Edelmann F, Filippatos G, Hasenfuß G, Haverkamp W, Lainscak M, Landmesser U, Macdougall IC, Merkely B, Pieske BM, Pinto FJ, Rassaf T, Visser-Rogers JK, et al
Intravenous Ferric Carboxymaltose in Heart Failure With Iron Deficiency: The FAIR-HF2 DZHK05 Randomized Clinical Trial
JAMA. 2025 Mar 30:e253833. doi: 10.1001/jama.2025.3833. Epub ahead of print
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Gabet A, Blacher J, Pousset F, Grave C, Lailler G, Tuppin P, Saadi M, Cohen A, Logeart D, Isnard R, Olié V
Epidemiology of heart failure in France. Epidémiologie de l,insuffisance cardiaque en France
Arch Cardiovasc Dis. 2024 Dec;117(12):705-714. doi: 10.1016/j.acvd.2024.10.004
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Jhund PS, Talebi A, Henderson AD, Claggett BL, Vaduganathan M, Desai AS, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Solomon SD, McMurray JJV
Mineralocorticoid receptor antagonists in heart failure: an individual patient level meta-analysis
Lancet. 2024 Sep 21;404(10458):1119-1131. doi: 10.1016/S0140-6736(24)01733-1
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FINEARTS-HF Committees and Investigators; Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Chang-Sheng M, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang S, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperón G, Mareev V, Martinez FA, Melenovský V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov L, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Kolkhof P, Viswanathan P
Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction
N Engl J Med. 2024 Sep 1. doi: 10.1056/NEJMoa2407107. Epub ahead of print
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Cox ZL, Collins SP, Hernandez GA, McRae AT 3rd, Davidson BT, Adams K, Aaron M, Cunningham L, Jenkins CA, Lindsell CJ, Harrell FE Jr, Kampe C, Miller KF, Stubblefield WB, Lindenfeld J
Efficacy and Safety of Dapagliflozin in Patients With Acute Heart Failure
J Am Coll Cardiol. 2024 Apr 9;83(14):1295-1306. doi: 10.1016/j.jacc.2024.02.009
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Yan L, Lu Y, Deng M, Zhang Q, Bian Y, Zhou X, Hou G
Efficacy of high-flow nasal cannula in patients with acute heart failure: a systematic review and meta-analysis
BMC Pulm Med. 2023 Nov 28;23(1):476. doi: 10.1186/s12890-023-02782-0
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Vaduganathan M, Mentz RJ, Claggett BL, Miao ZM, Kulac IJ, Ward JH, Hernandez AF, Morrow DA, Starling RC, Velazquez EJ, Williamson KM, Desai AS, Zieroth S, Lefkowitz M, McMurray JJV, Braunwald E, Solomon SD
Sacubitril/valsartan in heart failure with mildly reduced or preserved ejection fraction: a pre- specified participant-level pooled analysis of PARAGLIDE-HF and PARAGON-HF
Eur Heart J. 2023 Aug 14;44(31):2982-2993. doi: 10.1093/eurheartj/ehad344
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Diaz-Arocutipa C, Denegri-Galvan J, Vicent L, Pariona M, Mamas MA, Hernandez AV
The added value of hypertonic saline solution to furosemide monotherapy in patients with acute decompensated heart failure: A meta-analysis and trial sequential analysis
Clin Cardiol. 2023 Aug;46(8):853-865. doi: 10.1002/clc.24033
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Kittleson MM, Panjrath GS, Amancherla K, Davis LL, Deswal A, Dixon DL, Januzzi JL Jr, Yancy CW
2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure With Preserved Ejection Fraction: A Report of the American College of Cardiology Solution Set Oversight Committee
J Am Coll Cardiol. 2023 May 9;81(18):1835-1878. doi: 10.1016/j.jacc.2023.03.393
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Colin-Ramirez E, Sepehrvand N, Rathwell S, Ross H, Escobedo J, Macdonald P, Troughton R, Saldarriaga C, Lanas F, Doughty R, McAlister FA, Ezekowitz JA
Sodium Restriction in Patients With Heart Failure: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Circ Heart Fail. 2023 Jan;16(1):e009879. doi: 10.1161/CIRCHEARTFAILURE.122.009879
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Mebazaa A, Davison B, Chioncel O, Cohen-Solal A, Diaz R, Filippatos G, Metra M, Ponikowski P, Sliwa K, Voors AA, Edwards C, Novosadova M, Takagi K, Damasceno A, Saidu H, Gayat E, Pang PS, Celutkiene J, Cotter G
Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial
Lancet. 2022 Nov 4:S0140-6736(22)02076-1. doi: 10.1016/S0140-6736(22)02076-1
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Peikert A, Martinez FA, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Shah SJ, Katova T, Merkely B, Vardeny O, Wilderäng U, Lindholm D, Petersson M, Langkilde AM, McMurray JJV, Solomon SD
Efficacy and Safety of Dapagliflozin in Heart Failure With Mildly Reduced or Preserved Ejection Fraction According to Age: The DELIVER Trial
Circ Heart Fail. 2022 Oct;15(10):e010080. doi: 10.1161/CIRCHEARTFAILURE.122.010080
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Biegus J, Voors AA, Collins SP, Kosiborod MN, Teerlink JR, Angermann CE, Tromp J, Ferreira JP, Nassif ME, Psotka MA, Brueckmann M, Salsali A, Blatchford JP, Ponikowski P
Impact of empagliflozin on decongestion in acute heart failure: the EMPULSE trial
Eur Heart J. 2022 Oct 18:ehac530. doi: 10.1093/eurheartj/ehac530
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DELIVER Trial Committees and Investigators; Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Jhund PS, Belohlavek J, Chiang CE, Borleffs CJW, Comin-Colet J, Dobreanu D, Drozdz J, Fang JC, Alcocer-Gamba MA, Al Habeeb W, Han Y, Cabrera Honorio JW, Janssens SP, Katova T, Kitakaze M, Merkely B, O,Meara E, Saraiva JFK, Tereshchenko SN, Thierer J, Vaduganathan M, Vardeny O, Verma S, Pham VN, Wilderäng U, Zaozerska N, Bachus E, Lindholm D, Petersson M, Langkilde AM
Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction
N Engl J Med. 2022 Sep 22;387(12):1089-1098. doi: 10.1056/NEJMoa2206286
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Xiang B, Zhang R, Wu X, Zhou X
Optimal Pharmacologic Treatment of Heart Failure With Preserved and Mildly Reduced Ejection Fraction: A Meta-analysis
JAMA Netw Open. 2022 Sep 1;5(9):e2231963. doi: 10.1001/jamanetworkopen.2022.31963
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ADVOR Study Group; Mullens W, Dauw J, Martens P, Verbrugge FH, Nijst P, Meekers E, Tartaglia K, Chenot F, Moubayed S, Dierckx R, Blouard P, Troisfontaines P, Derthoo D, Smolders W, Bruckers L, Droogne W, Ter Maaten JM, Damman K, Lassus J, Mebazaa A, Filippatos G, Ruschitzka F, Dupont M
Acetazolamide in Acute Decompensated Heart Failure with Volume Overload
N Engl J Med. 2022 Aug 27. doi: 10.1056/NEJMoa2203094
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Schulze PC, Bogoviku J, Westphal J, Aftanski P, Haertel F, Grund S, von Haehling S, Schumacher U, Möbius-Winkler S, Busch M
Effects of Early Empagliflozin Initiation on Diuresis and Kidney Function in Patients With Acute Decompensated Heart Failure (EMPAG-HF)
Circulation. 2022 Jul 26;146(4):289-298. doi: 10.1161/CIRCULATIONAHA.122.059038
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EMPEROR-Preserved Trial Committees and Investigators; Böhm M, Butler J, Filippatos G, Ferreira JP, Pocock SJ, Abdin A, Mahfoud F, Brueckmann M, Gollop ND, Iwata T, Ponikowski P, Wanner C, Zannad F, Packer M, Anker SD
Empagliflozin Improves Outcomes in Patients With Heart Failure and Preserved Ejection Fraction Irrespective of Age
J Am Coll Cardiol. 2022 Jul 5;80(1):1-18. doi: 10.1016/j.jacc.2022.04.040
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SODIUM-HF Investigators; Ezekowitz JA, Colin-Ramirez E, Ross H, Escobedo J, Macdonald P, Troughton R, Saldarriaga C, Alemayehu W, McAlister FA, Arcand J, Atherton J, Doughty R, Gupta M, Howlett J, Jaffer S, Lavoie A, Lund M, Marwick T, McKelvie R, Moe G, Pandey AS, Porepa L, Rajda M, Rheault H, Singh J, Toma M, Virani S, Zieroth S
Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial
Lancet. 2022 Apr 9;399(10333):1391-1400. doi: 10.1016/S0140-6736(22)00369-5
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Tromp J, Ouwerkerk W, van Veldhuisen DJ, Hillege HL, Richards AM, van der Meer P, Anand IS, Lam CSP, Voors AA
A Systematic Review and Network Meta-Analysis of Pharmacological Treatment of Heart Failure With Reduced Ejection Fraction
JACC Heart Fail. 2022 Feb;10(2):73-84. doi: 10.1016/j.jchf.2021.09.004
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Kapelios CJ, Bonou Μ, Malliaras K, Athanasiadi E, Vakrou S, Skouloudi M, Masoura C, Barbetseas J
Association of loop diuretics use and dose with outcomes in outpatients with heart failure: a systematic review and meta-analysis of observational studies involving 96,959 patients
Heart Fail Rev. 2022 Jan;27(1):147-161. doi: 10.1007/s10741-020-09995-z
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Fudim M, Spates T, Sun JL, Kittipibul V, Testani JM, Starling RC, Tang WHW, Hernandez AF, Felker GM, O,Connor CM, Mentz RJ
Early diuretic strategies and the association with In-hospital and Post-discharge outcomes in acute heart failure
Am Heart J. 2021 Sep;239:110-119. doi: 10.1016/j.ahj.2021.05.011
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EMPEROR-Preserved Trial Investigators; Anker SD, Butler J, Filippatos G, Ferreira JP, Bocchi E, Böhm M, Brunner-La Rocca HP, Choi DJ, Chopra V, Chuquiure-Valenzuela E, Giannetti N, Gomez-Mesa JE, Janssens S, Januzzi JL, Gonzalez-Juanatey JR, Merkely B, Nicholls SJ, Perrone SV, Piña IL, Ponikowski P, Senni M, Sim D, Spinar J, Squire I, Taddei S, Tsutsui H, Verma S, Vinereanu D, Zhang J, Carson P, Lam CSP, Marx N, Zeller C, Sattar N, Jamal W, Schnaidt S, Schnee JM, Brueckmann M, Pocock SJ, Zannad F, Packer M
Empagliflozin in Heart Failure with a Preserved Ejection Fraction
N Engl J Med. 2021 Aug 27. doi: 10.1056/NEJMoa2107038. Epub ahead of print
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Liu C, Peng Z, Gao X, Gajic O, Dong Y, Prokop LJ, Murad MH, Kashani KB, Domecq JP
Simultaneous Use of Hypertonic Saline and IV Furosemide for Fluid Overload: A Systematic Review and Meta-Analysis
Crit Care Med. 2021 Jun 24. doi: 10.1097/CCM.0000000000005174. Online ahead of print
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Martin N, Manoharan K, Davies C, Lumbers RT
Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction
Cochrane Database Syst Rev. 2021 May 22;5(5):CD012721. doi: 10.1002/14651858.CD012721.pub3
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Kitzman DW, Whellan DJ, Duncan P, Pastva AM, Mentz RJ, Reeves GR, Nelson MB, Chen H, Upadhya B, Reed SD, Espeland MA, Hewston L, O,Connor CM
Physical Rehabilitation for Older Patients Hospitalized for Heart Failure
N Engl J Med. 2021 Jul 15;385(3):203-216. doi: 10.1056/NEJMoa2026141
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Yonathan Freund, Marine Cachanado, Quentin Delannoy, Said Laribi, Youri Yordanov, Judith Gorlicki, Tahar Chouihed, Anne-Laure Féral-Pierssens, Jennifer Truchot, Thibaut Desmettre, Celine Occelli, Xavier Bobbia, Mehdi Khellaf, Olivier Ganansia, Jérôme Bokobza, Frédéric Balen, Sebastien Beaune, Ben Bloom, Tabassome Simon, Alexandre Mebazaa
Effect of an Emergency Department Care Bundle on 30-Day Hospital Discharge and Survival Among Elderly Patients With Acute Heart Failure: The ELISABETH Randomized Clinical Trial
JAMA. 2020 Nov 17;324(19):1948-1956. doi: 10.1001/jama.2020.19378.
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Packer , Anker , Butler , Filippatos , Pocock , Carson , Januzzi , Verma , Tsutsui , Brueckmann , Jamal , Kimura , Schnee , Zeller , Cotton , Bocchi , Böhm , Choi , Chopra , Chuquiure , Giannetti , Janssens , Zhang , Gonzalez Juanatey , Kaul , Brunner-La Rocca , Merkely , Nicholls , Perrone , Pina , Ponikowski , Sattar , Senni , Seronde , Spinar , Squire , Taddei , Wanner , Zannad , EMPEROR-Reduced Trial Investigators ,
Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure.
N Engl J Med. 2020 Oct 8;383(15):1413-1424. doi: 10.1056/NEJMoa2022190
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VICTORIA Study Group; Paul W Armstrong, Burkert Pieske, Kevin J Anstrom, Justin Ezekowitz, Adrian F Hernandez, Javed Butler, Carolyn S P Lam, Piotr Ponikowski, Adriaan A Voors, Gang Jia, Steven E McNulty, Mahesh J Patel, Lothar Roessig, Joerg Koglin, Christopher M O,Connor
Vericiguat in Patients With Heart Failure and Reduced Ejection Fraction
N Engl J Med. 2020 May 14;382(20):1883-1893
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Simone Frea, Stefano Pidello, Alessandra Volpe, Federico Giovanni Canavosio, Alessandro Galluzzo, Virginia Bovolo, Antonio Camarda, Pier Giorgio Golzio, Fabrizio D,Ascenzo, Serena Bergerone, Mauro Rinaldi, Fiorenzo Gaita
Diuretic treatment in high-risk acute decompensation of advanced chronic heart failure-bolus intermittent vs. continuous infusion of furosemide: a randomized controlled trial
Clin Res Cardiol. 2020 Apr;109(4):417-425. doi: 10.1007/s00392-019-01521-y. Epub 2019 Jun 29.
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Oh GC, Cho HJ, Lee SE, Kim MS, Kim JJ, Choi JO, Jeon ES, Hwang KK, Chae SC, Baek SH, Kang SM, Yoo BS, Choi DJ, Ahn Y, Kim KH, Cho MC, Oh BH, Lee HY
Management and Prognosis of Heart Failure in Octogenarians: Final Report from the KorAHF Registry
J Clin Med. 2020 Feb 12;9(2):501. doi: 10.3390/jcm9020501
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DAPA-HF Trial Committees and Investigators; McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Bělohlávek J, Böhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, Diez M, Drozdz J, Dukát A, Ge J, Howlett JG, Katova T, Kitakaze M, Ljungman CEA, Merkely B, Nicolau JC, O'Meara E, Petrie MC, Vinh PN, Schou M, Tereshchenko S, Verma S, Held C, DeMets DL, Docherty KF, Jhund PS, Bengtsson O, Sjöstrand M, Langkilde AM
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction
N Engl J Med. 2019 Nov 21;381(21):1995-2008. doi: 10.1056/NEJMoa1911303
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PARAGON-HF Investigators and Committees; Solomon SD, McMurray JJV, Anand IS, Ge J, Lam CSP, Maggioni AP, Martinez F, Packer M, Pfeffer MA, Pieske B, Redfield MM, Rouleau JL, van Veldhuisen DJ, Zannad F, Zile MR, Desai AS, Claggett B, Jhund PS, Boytsov SA, Comin-Colet J, Cleland J, Düngen HD, Goncalvesova E, Katova T, Kerr Saraiva JF, Lelonek M, Merkely B, Senni M, Shah SJ, Zhou J, Rizkala AR, Gong J, Shi VC, Lefkowitz MP
Angiotensin-Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction
N Engl J Med. 2019 Oct 24;381(17):1609-1620. doi: 10.1056/NEJMoa1908655
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Taylor RS, Walker S, Ciani O, Warren F, Smart NA, Piepoli M5, Davos CH
Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis
Health Technol Assess. 2019 May;23(25):1-98
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Palmer K, Bowles KA, Paton M, Jepson M, Lane R
Chronic Heart Failure and Exercise Rehabilitation: A Systematic Review and Meta-Analysis
Arch Phys Med Rehabil. 2018 Dec;99(12):2570-2582
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Shah KS, Xu H, Matsouaka RA, Bhatt DL, Heidenreich PA, Hernandez AF, Devore AD, Yancy CW, Fonarow GC
Heart Failure With Preserved, Borderline, and Reduced Ejection Fraction: 5-Year Outcomes
J Am Coll Cardiol. 2017 Nov 14;70(20):2476-2486. doi: 10.1016/j.jacc.2017.08.074
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Stienen Salah Moons Bakx van Pol Kortz Ferreira Marques Schroeder-Tanka Keijer Bayés-Genis Tijssen Pinto Kok
NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure: PRIMA II Randomized Controlled Trial
Circulation. 2018 Apr 17;137(16):1671-1683
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Zheng SL, Chan FT, Nabeebaccus AA, Shah AM, McDonagh T, Okonko DO, Ayis S
Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis
Heart. 2018 Mar;104(5):407-415. doi: 10.1136/heartjnl-2017-311652
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Faris RF, Flather M, Purcell H, Poole-Wilson PA, Coats AJ
WITHDRAWN: Diuretics for heart failure
Cochrane Database Syst Rev. 2016 Apr 4;4(4):CD003838. doi: 10.1002/14651858.CD003838.pub4
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Martindale Wakai Collins Levy Diercks Hiestand Fermann deSouza Sinert
Diagnosing Acute Heart Failure in the Emergency Department: A Systematic Review and Meta-analysis.
Acad Emerg Med. 2016 Mar;23(3):223-42
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PARADIGM-HF Investigators and Committees; McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR
Angiotensin-neprilysin inhibition versus enalapril in heart failure
N Engl J Med. 2014 Sep 11;371(11):993-1004. doi: 10.1056/NEJMoa1409077
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Goldenberg I, Kutyifa V, Klein HU, Cannom DS, Brown MW, Dan A, Daubert JP, Estes 3rd, Foster E, Greenberg H, Kautzner J, Klempfner R, Kuniss M, Merkely B, Pfeffer MA, Quesada A, Viskin S, McNitt S, Polonsky B, Ghanem A, Solomon SD, Wilber D, Zareba W, Moss AJ
Survival with cardiac-resynchronization therapy in mild heart failure
N Engl J Med. 2014 May 1;370(18):1694-701
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TOPCAT Investigators, Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Harty B, Heitner JF, Kenwood CT, Lewis EF, O,Meara E, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, Yang S, McKinlay SM
Spironolactone for heart failure with preserved ejection fraction
N Engl J Med. 2014 Apr 10;370(15):1383-92
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Tuppin Cuerq de Peretti Fagot-Campagna Danchin Juillière Alla Allemand Bauters Drici Hagège Jondeau Jourdain Leizorovicz Paccaud
Two-year outcome of patients after a first hospitalization for heart failure: A national observational study.
Arch Cardiovasc Dis. 2014 Mar;107(3):158-68
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Liu F, Chen Y, Feng X, Teng Z, Yuan Y, Bin J
Effects of beta-blockers on heart failure with preserved ejection fraction: a meta-analysis
PLoS One. 2014;9(3):e90555
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Makani H, Bangalore S, Desouza KA, Shah A, Messerli FH,
Efficacy and safety of dual blockade of the renin-angiotensin system: meta-analysis of randomised trials.
BMJ. 2013 Jan 28;346:f360. doi: 10.1136/bmj.f360.
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Takeda A, Taylor SJ, Taylor RS, Khan F, Krum H, Underwood M
Clinical service organisation for heart failure
Cochrane Database Syst Rev. 2012;9:CD002752
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Stewart S, Carrington MJ, Marwick TH, Davidson PM, Macdonald P, Horowitz JD, Krum H, Newton PJ, Reid C, Chan YK, Scuffham PA,
Impact of Home Versus Clinic-Based Management of Chronic Heart Failure: The WHICH? (Which Heart Failure Intervention Is Most Cost-Effective ? Consumer Friendly in Reducing Hospital Care) Multicenter, Randomized Trial.
J Am Coll Cardiol. 2012 Oct 2;60(14):1239-48
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Januzzi Jr, Rehman SU, Mohammed AA, Bhardwaj A, Barajas L, Barajas J, Kim HN, Baggish AL, Weiner RB, Chen-Tournoux A, Marshall JE, Moore SA, Carlson WD, Lewis GD, Shin J, Sullivan D, Parks K, Wang TJ, Gregory SA, Uthamalingam S, Semigran MJ
Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction
J Am Coll Cardiol. 2011 Oct 25;58(18):1881-9
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Holland DJ, Kumbhani DJ, Ahmed SH, Marwick TH,
Effects of treatment on exercise tolerance, cardiac function, and mortality in heart failure with preserved ejection fraction. A meta-analysis.
J Am Coll Cardiol. 2011 Apr 19;57(16):1676-86
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Felker GM, Lee KL, Bull DA, Redfield MM, Stevenson LW, Goldsmith SR, LeWinter MM, Deswal A, Rouleau JL, Ofili EO, Anstrom KJ, Hernandez AF, McNulty SE, Velazquez EJ, Kfoury AG, Chen HH, Givertz MM, Semigran MJ, Bart BA, Mascette AM, Braunwald E, O,Connor CM, NHLBI Heart Failure Clinical Research Network NHLBI Heart Failure Clinical Research Network,
Diuretic strategies in patients with acute decompensated heart failure.
N Engl J Med. 2011 Mar 3;364(9):797-805. doi: 10.1056/NEJMoa1005419
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EMPHASIS-HF Study Group, Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pocock SJ, Pitt B
Eplerenone in patients with systolic heart failure and mild symptoms
N Engl J Med. 2011 Jan 6;364(1):11-21
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Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators, Tang AS, Wells GA, Talajic M, Arnold MO, Sheldon R, Connolly S, Hohnloser SH, Nichol G, Birnie DH, Sapp JL, Yee R, Healey JS, Rouleau JL
Cardiac-resynchronization therapy for mild-to-moderate heart failure
N Engl J Med. 2010 Dec 16;363(25):2385-95
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Swedberg K, Komajda M, Böhm M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L, SHIFT Investigators SHIFT Investigators,
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study.
Lancet. 2010 Sep 11;376(9744):875-85
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Desai A, Lewis E, Solomon S, McMurray JJ, Pfeffer M,
Impact of erythropoiesis-stimulating agents on morbidity and mortality in patients with heart failure: an updated, post-TREAT meta-analysis.
Eur J Heart Fail. 2010 Sep;12(9):936-42
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Porapakkham P, Porapakkham P, Zimmet H, Billah B, Krum H
B-type natriuretic peptide-guided heart failure therapy: A meta-analysis
Arch Intern Med. 2010 Mar 22;170(6):507-14
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Berger R, Moertl D, Peter S, Ahmadi R, Huelsmann M, Yamuti S, Wagner B, Pacher R
N-terminal pro-B-type natriuretic peptide-guided, intensive patient management in addition to multidisciplinary care in chronic heart failure a 3-arm, prospective, randomized pilot study
J Am Coll Cardiol. 2010 Feb 16;55(7):645-53
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Ngo K, Kotecha D, Walters JA, Manzano L, Palazzuoli A, van Veldhuisen DJ, Flather M
Erythropoiesis-stimulating agents for anaemia in chronic heart failure patients
Cochrane Database Syst Rev. 2010;1(1):CD007613
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Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, Estes 3rd, Foster E, Greenberg H, Higgins SL, Pfeffer MA, Solomon SD, Wilber D, Zareba W, MADIT-CRT Trial Investigators MADIT-CRT Trial Investigators,
Cardiac-resynchronization therapy for the prevention of heart-failure events.
N Engl J Med. 2009 Oct 1;361(14):1329-38
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B-CONVINCED Investigators; Jondeau G, Neuder Y, Eicher JC, Jourdain P, Fauveau E, Galinier M, Jegou A, Bauer F, Trochu JN, Bouzamondo A, Tanguy ML, Lechat P
B-CONVINCED: Beta-blocker CONtinuation Vs. INterruption in patients with Congestive heart failure hospitalizED for a decompensation episode
Eur Heart J. 2009 Sep;30(18):2186-92
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Somaratne JB, Berry C, McMurray JJ, Poppe KK, Doughty RN, Whalley GA
The prognostic significance of heart failure with preserved left ventricular ejection fraction: a literature-based meta-analysis
Eur J Heart Fail. 2009 Sep;11(9):855-62
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SENIORS Investigators, van Veldhuisen DJ, Cohen-Solal A, Böhm M, Anker SD, Babalis D, Roughton M, Coats AJ, Poole-Wilson PA, Flather MD
Beta-blockade with nebivolol in elderly heart failure patients with impaired and preserved left ventricular ejection fraction: Data From SENIORS (Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors With Heart Failure)
J Am Coll Cardiol. 2009 Jun 9;53(23):2150-8
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Maestre A, Gil V, Gallego J, Aznar J, Mora A, Martín-Hidalgo A,
Diagnostic accuracy of clinical criteria for identifying systolic and diastolic heart failure: cross-sectional study.
J Eval Clin Pract. 2009 Feb;15(1):55-61
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Jhund PS, Macintyre K, Simpson CR, Lewsey JD, Stewart S, Redpath A, Chalmers JW, Capewell S, McMurray JJ
Long-term trends in first hospitalization for heart failure and subsequent survival between 1986 and 2003: a population study of 5.1 million people
Circulation. 2009 Feb 3;119(4):515-23
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Hernandez AF, Hammill BG, O,Connor CM, Schulman KA, Curtis LH, Fonarow GC
Clinical effectiveness of beta-blockers in heart failure: findings from the OPTIMIZE-HF (Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure) Registry
J Am Coll Cardiol. 2009 Jan 13;53(2):184-92. doi: 10.1016/j.jacc.2008.09.031
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Pfisterer M, Buser P, Rickli H, Gutmann M, Erne P, Rickenbacher P, Vuillomenet A, Jeker U, Dubach P, Beer H, Yoon SI, Suter T, Osterhues HH, Schieber MM, Hilti P, Schindler R, Brunner-La Rocca HP, TIME-CHF Investigators TIME-CHF Investigators,
BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial.
JAMA. 2009 Jan 28;301(4):383-92
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3CPO Trialists; Gray A, Goodacre S, Newby DE, Masson M, Sampson F, Nicholl J
Noninvasive ventilation in acute cardiogenic pulmonary edema
N Engl J Med. 2008 Jul 10;359(2):142-51
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Phillips CO, Kashani A, Ko DK, Francis G, Krumholz HM
Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from randomized clinical trials
Arch Intern Med. 2007 Oct 8;167(18):1930-6
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Remme WJ, Torp-Pedersen C, Cleland JG, Poole-Wilson PA, Metra M, Komajda M, Swedberg K, Di Lenarda A, Spark P, Scherhag A, Moullet C, Lukas MA,
Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET.
J Am Coll Cardiol. 2007 Mar 6;49(9):963-71
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Goldberg RJ, Ciampa J, Lessard D, Meyer TE, Spencer FA
Long-term survival after heart failure: a contemporary population-based perspective
Arch Intern Med. 2007 Mar 12;167(5):490-6
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PEP-CHF Investigators, Cleland JG, Tendera M, Adamus J, Freemantle N, Polonski L, Taylor J
The perindopril in elderly people with chronic heart failure (PEP-CHF) study
Eur Heart J. 2006 Oct;27(19):2338-45
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Ahmed A, Rich MW, Fleg JL, Zile MR, Young JB, Kitzman DW, Love TE, Aronow WS, Adams KF Jr, Gheorghiade M
Effects of digoxin on morbidity and mortality in diastolic heart failure: the ancillary digitalis investigation group trial
Circulation. 2006 Aug 1;114(5):397-403. Epub 2006 Jul 24
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Bhatia RS, Tu JV, Lee DS, Austin PC, Fang J, Haouzi A, Gong Y, Liu PP
Outcome of heart failure with preserved ejection fraction in a population-based study
N Engl J Med. 2006 Jul 20;355(3):260-9
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Owan TE, Hodge DO, Herges RM, Jacobsen SJ, Roger VL, Redfield MM
Trends in prevalence and outcome of heart failure with preserved ejection fraction
N Engl J Med. 2006 Jul 20;355(3):251-9
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Ahmed A, Husain A, Love TE, Gambassi G, Dell,italia LJ, Francis GS, Gheorghiade M, Allman RM, Meleth S, Bourge RC
Heart failure, chronic diuretic use, and increase in mortality and hospitalization: an observational study using propensity score methods
Eur Heart J. 2006 Jun;27(12):1431-1439. Epub 2006 May 18
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Levy WC, Mozaffarian D, Linker DT, Sutradhar SC, Anker SD, Cropp AB, Anand I, Maggioni A, Burton P, Sullivan MD, Pitt B, Poole-Wilson PA, Mann DL, Packer M,
The Seattle Heart Failure Model: prediction of survival in heart failure.
Circulation. 2006 Mar 21;113(11):1424-33
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Wang CS, FitzGerald JM, Schulzer M, Mak E, Ayas NT
Does this dyspneic patient in the emergency department have congestive heart failure?
JAMA. 2005 Oct 19;294(15):1944-56
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Sanders GD, Hlatky MA, Owens DK
Cost-effectiveness of implantable cardioverter-defibrillators
N Engl J Med. 2005 Oct 6;353(14):1471-80
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EPHESUS Investigators; Pitt B, White H, Nicolau J, Martinez F, Gheorghiade M, Aschermann M, van Veldhuisen DJ, Zannad F, Krum H, Mukherjee R, Vincent J
Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure
J Am Coll Cardiol. 2005 Aug 2;46(3):425-31
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Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators; Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, Tavazzi L
The effect of cardiac resynchronization on morbidity and mortality in heart failure
N Engl J Med. 2005 Apr 14;352(15):1539-49
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SENIORS Investigators, Flather MD, Shibata MC, Coats AJ, Van Veldhuisen DJ, Parkhomenko A, Borbola J, Cohen-Solal A, Dumitrascu D, Ferrari R, Lechat P, Soler-Soler J, Tavazzi L, Spinarova L, Toman J, Böhm M, Anker SD, Thompson SG, Poole-Wilson PA
Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)
Eur Heart J. 2005 Feb;26(3):215-25
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Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R, Domanski M, Troutman C, Anderson J, Johnson G, McNulty SE, Clapp-Channing N, Davidson-Ray LD, Fraulo ES, Fishbein DP, Luceri RM, Ip JH
Amiodarone or an Implantable Cardioverter-Defibrillator for Congestive Heart Failure
N Engl J Med. 2005 Jan 20;352(3):225-237
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Desai AS, Fang JC, Maisel WH, Baughman KL
Implantable defibrillators for the prevention of mortality in patients with nonischemic cardiomyopathy: a meta-analysis of randomized controlled trials
JAMA. 2004 Dec 15;292(23):2874-9
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African-American Heart Failure Trial Investigators; Taylor AL, Ziesche S, Yancy C, Carson P, D,Agostino R Jr, Ferdinand K, Taylor M, Adams K, Sabolinski M, Worcel M, Cohn JN
Combination of isosorbide dinitrate and hydralazine in blacks with heart failure
N Engl J Med. 2004 Nov 11;351(20):2049-57. Epub 2004 Nov 8
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Lee VC, Rhew DC, Dylan M, Badamgarav E, Braunstein GD, Weingarten SR
Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarction
Ann Intern Med. 2004 Nov 2;141(9):693-704
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Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators; Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, Carson P, DiCarlo L, DeMets D, White BG, DeVries DW, Feldman AM
Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure
N Engl J Med. 2004 May 20;350(21):2140-50
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Nanas JN, Tsagalou EP, Kanakakis J, Nanas SN, Terrovitis JV, Moon T, Anastasiou-Nana MI
Long-term intermittent dobutamine infusion, combined with oral amiodarone for end-stage heart failure: a randomized double-blind study
Chest. 2004 Apr;125(4):1198-204
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Mueller C, Scholer A, Laule-Kilian K, Martina B, Schindler C, Buser P, Pfisterer M, Perruchoud AP
Use of B-type natriuretic peptide in the evaluation and management of acute dyspnea
N Engl J Med. 2004 Feb 12;350(7):647-54
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Yusuf S, Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL, Olofsson B, Ostergren J; CHARM Investigators and Committees
Effects of candesartan in patients with chronic heart failure and preserved left-ventricular ejection fraction: the CHARM-Preserved Trial
Lancet. 2003 Sep 6;362(9386):777-81
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Granger CB, McMurray JJ, Yusuf S, Held P, Michelson EL, Olofsson B, Ostergren J, Pfeffer MA, Swedberg K; CHARM Investigators and Committees
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial
Lancet. 2003 Sep 6;362(9386):772-6
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McMurray JJ, Ostergren J, Swedberg K, Granger CB, Held P, Michelson EL, Olofsson B, Yusuf S, Pfeffer MA; CHARM Investigators and Committees
Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function taking angiotensin-converting-enzyme inhibitors: the CHARM-Added trial
Lancet. 2003 Sep 6;362(9386):767-71
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Breathing Not Properly Multinational Study Investigators; Maisel AS, Krishnaswamy P, Nowak RM, McCord J, Hollander JE, Duc P, Omland T, Storrow AB, Abraham WT, Wu AH, Clopton P, Steg PG, Westheim A, Knudsen CW, Perez A, Kazanegra R, Herrmann HC, McCullough PA
Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
N Engl J Med. 2002 Jul 18;347(3):161-7
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Feenstra J, Heerdink ER, Grobbee DE, Stricker BH
Association of nonsteroidal anti-inflammatory drugs with first occurrence of heart failure and with relapsing heart failure: the Rotterdam Study
Arch Intern Med. 2002 Feb 11;162(3):265-70
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Lynn Caruana, Mark C Petrie, Andrew P Davie, John J V McMurray
Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? A prospective descriptive study
BMJ. 2000 Jul 22;321(7255):215-8
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Flather MD, Yusuf S, Kober L, Pfeffer M, Hall A, Murray G, Torp-Pedersen C, Ball S, Pogue J, Moye L, Braunwald E
Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. ACE-Inhibitor Myocardial Infarction Collaborative Group
Lancet. 2000 May 6;355(9215):1575-1581
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Pitt B, Poole-Wilson PA, Segal R, Martinez FA, Dickstein K, Camm AJ, Konstam MA, Riegger G, Klinger GH, Neaton J, Sharma D, Thiyagarajan B, on behalf of the ELITE II investigators
Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial. The Losartan Heart Failure Survival Study ELITE II
Lancet. 2000 May 6;355(9215):1582-1587
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Page J, Henry D
Consumption of NSAIDs and the Development of Congestive Heart Failure in Elderly Patients. An Underrecognized Public Health Problem
Arch Intern Med. 2000 Mar 27;160(6):777-784
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Hjalmarson A, Goldstein S, Fagerberg B, et al., for the MERIT-HF Study Group
Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF)
JAMA. 2000 Mar 8;283(10):1295-302
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Bertram Pitt, Faiez Zannad, Willem J. Remme, Robert Cody, Alain Castaigne, Alfonso Perez, Jolie Palensky, Janet Wittes
The Effect of Spironolactone on Morbidity and Mortality in Patients with Severe Heart Failure. Randomized Aldactone Evaluation Study (RALES) Investigators
N Engl J Med. 1999 Sept 2;341(10):709-17
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Belardinelli R, Georgiou D, Cianci G, Purcaro A
Randomized, controlled trial of long-term moderate exercise training in chronic heart failure. Effects on functional capacity, quality of life, and clinical outcome
Circulation. 1999 Mar 9;99:1173-82
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Harf C, Welter R
Emergency treatment of severe cardiogenic pulmonary edema with intravenous isosorbide-5-mononitrate
Am J Cardiol. 1988 Mar 25;61(9):22E-27E
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Cotter G, Metzkor E, Kaluski E, Faigenberg Z, Miller R, Simovitz A, Shaham O, Marghitay D, Koren M, Blatt A, Moshkovitz Y, Zaidenstein R, Golik A
Randomised trial of high-dose isosorbide dinitrate plus low-dose furosemide versus high-dose furosemide plus low-dose isosorbide dinitrate in severe pulmonary oedema.
Lancet. 1998 Feb 7;351(9100):389-93
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Philippe Lechat, Milton Packer, Stephan Chalon, Michel Cucherat, Tarek Arab, Jean-Pierre Boissel
Clinical Effects of ß-Adrenergic Blockade in Chronic Heart Failure. A Meta-Analysis of Double-Blind, Placebo-Controlled, Randomized Trials
Circulation. 1998;98:1184-1191.
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Pitt B, Segal R, Martinez FA, Meurers G, Cowley AJ, Thomas I, Deedwania PC, Ney DE, Snavely DB, Chang PI
Randomised trial of losartan versus captopril in patients over 65 with heart failure. Evaluation of Losartan in the Elderly Study, ELITE-I
Lancet. 1997 Mar 15;349(9054):747-52
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Australia/New Zealand Heart Failure Research Collaborative Group
Randomised, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischaemic heart disease
Lancet. 1997 Feb 8;349(9049):375-80
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Garg R, Gorlin R, Smith T, Yusuf S, for the Digitalis Investigation Group
The effect of digoxin on mortality and morbidity in patients with heart failure. The Digitalis Investigation Group
N Engl J Med. 1997 Feb 20;336(8):525-33
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Packer M, O'Connor CM, Ghali JK, Pressler ML, Carson PE, Belkin RN, Miller AB, Neuberg GW, Frid D, Wertheimer JH, Cropp AB, DeMets DL
Effect of amlodipine on morbidity and mortality in severe chronic heart failure. PRAISE (Prospective Randomized Amlodipine Survival Evaluation)
N Engl J Med. 1996 Oct 10;335(15):1107-14
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Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM, Shusterman NH
The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group
N Engl J Med. 1996 May 23;334(21):1349-55