Acute hypoxic respiratory failure: Lower versus Higher Oxygenation targets
DISEASE	INTERVENTION	COMPARISON	RESULTS
Lancet. 2018 Apr 28;391(10131):1693-1705		Systematic Review
IN acutely ill adults, emergency care	The Use of conservative oxygen therapy with a SpO2 of 94-96% as objective As Treatment, Acute	Is better Than liberal oxygen therapy, with SpO2 > 96%	To reduce overall mortality at 30 days and longuer: liberal oxygen therapy increased mortality (RR 1.14 at 30 days)
N Engl J Med. 2021 Jan 20. doi: 10.1056/NEJMoa2032510. Online ahead of print		Randomized Controlled Trial, Multicenter Study
IN respiratory failure, acute, hypoxic, acutely ill adults, emergency care	The Use of oxygen therapy targeting a Pao2 of 60 mm Hg As Treatment, Acute	Is equal Than oxygen therapy targeting a Pao2 of 90 mm Hg	To modify death at 3 months (42% in both groups). No difference neither in days that patients were alive without life support, episodes of shock, myocardial ischemia, ischemic stroke, or intestinal ischemia