Background
DISEASE INTERVENTION COMPARISON RESULTS
Am J Cardiol. 2003 Mar 20;91(6A):15D-26D Review (Narrative)
IN atrial fibrillation The Use of
diverse antiarrhythmic drugs
As Treatment, Chronic
Is useful Than
diverse other antiarrhythmic drugs
To not quantifiable outcomes here
Heart. 2001 Nov;86(5):516-21 Cohorts
IN atrial fibrillation, general population, prevalence, incidence The Use of
general population prevalence and incidence
As Undefined
Is useful Than
no comparison here.
To population prevalence of AF was 6.5 cases/1000 examinations. Incidence of AF was 0.54 cases/1000 person years
Am J Cardiol. 2003 Mar 20;91(6A):2D-8D Review (Narrative)
IN atrial fibrillation, heart failure The Use of
incidence, prevalence, patophysiology
As -
Is useful Than
-
To Different factors create an environment in which HF predisposes to AF and AF exacerbates HF. Although therapeutic options for AF are varied, their effect on prognosis remains unknown.
Circulation. 2003 Sep 9;108 Suppl 1:II207-12 Cohorts
IN atrial fibrillation, postoperative, cardiac surgery The Use of
incidence, natural history
As Prognostic Item
Is useful Than
-
To the incidence of AF for the first year following CABG is higher in patients <70 years but not in those >70 years when compared with the general population. AF was associated to postoperative infection and renal dysfunction
Circulation. 1998 Sep 8;98(10):946-52 Cohorts
IN StudyID: Benjamin 1998, atrial fibrillation, mortality The Use of
mortality, risk excess associated to AF
As Prognostic Item
Is useful Than
-
To AF was associated with an OR for death of 1.5 to 1.9 (men - women) after adjustment for several factors
Am Heart J. 2000 May;139(5):752-60 Review (Narrative)
IN StudyID: Connolly 2000, atrial fibrillation The Use of
appropiate outcome measures: longer-term risks of stroke or death and patient quality of life
As -
Is better Than
just AF recurrences at ECG
To showing whether AF suppression reduces the longer-term risks of stroke or death and improves patient quality of life. AF recurrences that are symptomatic and therefore relevant to the patient also.
J Am Coll Cardiol. 1992 Sep;20(3):527-32 Randomized Controlled Trial
IN StudyID: Flaker 1992, atrial fibrillation, pro-arrhythmia The Use of
diverse antiarrhythmic drugs
As Treatment, Chronic
Is worse Than
no treatment
To overall mortality, specially in patients with heart failure
Am J Cardiol. 1995 Aug 15;76(5):355-8 Descriptive
IN StudyID: Flaker 1995, atrial fibrillation The Use of
risk factors for recurrence and persistence, clinical and echocardiography data
As Prognostic Item
Is useful Than
-
To Clinical factors predicting recurrent AF were age, heart failure, and myocardial infarction. At echocardiography, enlarged left atrium predicted recurrence of AF and enlarged left ventricle predicted conversion to constant AF.
Am J Cardiol. 1998 Oct 16;82(8A):50N-58N Review (Narrative)
IN StudyID: Friedman 1998, atrial fibrillation, pro-arrhythmia definition The Use of
criteria to define proarrhythmia
As Diagnostic Tool
Is useful Than
-
To characterize toxicity of drugs
Am J Cardiol. 1994 Aug 1;74(3):236-41 Descriptive
IN StudyID: Furberg 1994, atrial fibrillation The Use of
aetiology: coexistence of clinical or subclinical cardiovascular disease, prevalence of AF
As -
Is - Than
-
To AF existed 4.8% of women and in 6.2% of men > 65 years. The observed low prevalence of AF in the absence of sub/clinical cardiovascular disease calls into question the existence of so-called "lone AF" in the elderly
J Cardiol 2001 Feb;37(2):103-7 Descriptive
IN StudyID: Geleris 2001, atrial fibrillation, recent-onset The Use of
rate of spontaneous conversion to sinus rhythm
As Prognostic Item
Is - Than
-
To occurred in 71% of patients, mostly in first 12 hr. Left atrial size was the only predictor of spontaneous conversion. Age, gender, other clinical characteristics, left ventricular dimensions and performance did not predict.
JAMA 2001 May 9;285(18):2370-5 Descriptive, Cross-Sectional Study
IN StudyID: Go 2001, atrial fibrillation The Use of
prevalence, in an study population of 1.89 million at the USA
As -
Is useful Than
-
To planning health resources. The global prevalence of AF was 0.95%, it increased from 0.1% among adults < 55 years to 9.0% in those > 80 years
Ann Intern Med 1996 Aug 15;125(4):311-23 Review (Narrative)
IN StudyID: Golzari 1996, atrial fibrillation, existing meta-analysis The Use of
diverse antiarrhythmic drugs
As Treatment, Chronic
Is better Than
no treatment
To restoring and maintaining sinus rhythm
Am J Med. 1995 May;98(5):476-84 Descriptive, propspective
IN StudyID: Krahn 1995, atrial fibrillation, natural history The Use of
incidence, aetiology, natural history: associated risk of death, stroke and heart failure
As Prognostic Item
Is useful Than
-
To Incidence rose with age, associated to ischemic heart disease, hypertension and otrher cardiac diseases. AF independently increased the risk for stroke (RR 2.07), congestive heart failure (RR 2.98) and total mortality (RR 1.31)
Circulation. 1999 Jun 15;99(23):3028-35 Cohorts
IN StudyID: Levy 1999, atrial fibrillation The Use of
natural history of AF by type and aetiology
As Prognostic Item
Is useful Than
-
To -
MMWR Morb Mortal Wkly Rep 2003 Feb 21;52(7):128, 130-1 Descriptive
IN StudyID: MMWR 2003, atrial fibrillation, epidemiology The Use of
mortality, AF as contributing cause of
As Prognostic Item
Is useful Than
-
To The frequency with which AF is reported on death certificates as a contributing cause of death has increased since 1980, primarily in persons aged > 75 years
Circulation. 1991 Nov;84(5):1977-83 Meta-Analysis
IN StudyID: Morganroth 1991, ventricular tachycardia, antiarrhythmics mortality The Use of
quinidine
As Treatment, Chronic
Is worse Than
other class I antiarrhythmic drugs
To modify mortality: 2.3% quinidine VS 0.7% other class I drugs, p=0.05
Am J Cardiol. 2004 Dec 1;94(11):1379-82 Cohorts
IN StudyID: Patel 2004, atrial fibrillation, mortality The Use of
natural history, mortality
As Prognostic Item
Is useful Than
-
To AF is associated with higher mortality, even when main medical condition is not cardiac
Circulation. 1997 Oct 7;96(7):2455-61
IN StudyID: Psaty 1997, atrial fibrillation The Use of
aetiology: associated factors causing AF. Incidence of AF
As -
Is - Than
-
To A history of valvular heart disease, coronary disease, advancing age, higher levels of systolic blood pressure, height, glucose, and left atrial size were all associated with an increased risk of AF
J Clin Epidemiol 2002 Apr;55(4):358-63 Case-Control
IN StudyID: Ruigomez 2002, atrial fibrillation, persistent The Use of
incidence
As -
Is useful Than
-
To incidence rate of chronic AF was 1.7 per 1,000 person-years, and increased markedly with age. The major risk factors were age, high BMI, excessive alcohol consumption, and prior cardiovascular comorbidity. 40% did not receive either warfarin or aspirin
Am J Med. 2002 Oct 1;113(5):359-64 Cohorts
IN StudyID: Stewart 2002, atrial fibrillation The Use of
associated risks
As Prognostic Item
Is useful Than
0
To Atrial fibrillation is independently associated with an increased long-term risk of stroke, heart failure, and all-cause mortality
Circulation. 2003 Jun 17;107(23):2926-31 Randomized Controlled Trial
IN StudyID: Vermes 2003, atrial fibrillation, heart failure The Use of
angiotensing converting enzyme inhibitors, enalapril
As Treatment, Chronic
Is better Than
placebo
To reducing the risk of development of atrial fibrillation in patients with left ventricular dysfunction (at 3 years: 5,4% ACEi vs 24% placebo)
Arch Intern Med. 2003 Apr 28;163(8):936-43 Meta-Analysis
IN StudyID: Walraven 2003, atrial fibrillation The Use of
risk factors for stroke: several clinical items: previous stroke or TIA, hypertension, symptomatic coronary artery disease, and diabetes
As Prognostic Item
Is useful Than
-
To predicting risk of stroke: patients with AF and none of these 4 clinical features and who take aspirin have stroke rates comparable to those of age-matched community cohorts (1.2 events per 100 PYs) Age > 75 years was not predictive
Circulation. 2003 Aug 12;108(6):711-6 Descriptive
IN StudyID: Wattigney 2003, atrial fibrillation, epidemiology The Use of
atrial fibrillation, as contributing cause of hospitalization
As Prognostic Item
Is useful Than
no comparison here
To Hospitalizations for atrial fibrillation have increased dramatically (2- to 3-fold) in recent years