Atrial fibrillation: angiotensin system blockers to reduce recurrences after cardioversion
DISEASE INTERVENTION COMPARISON RESULTS
Circulation. 2002 Jul 16;106(3):331-6 Randomized Controlled Trial
IN atrial fibrillation, persistent The Use of
angiotensin II receptor blockers (irbesartan), added to amiodarone
As Treatment, Chronic
Is better Than
amiodarone alone
To reduce, at 9 months, recurrence of AF: 20% ibersartan plus VS 44% amiodarone alone
N Engl J Med. 2011 Mar 10;364(10):928-38 Randomized Controlled Trial, Multicenter Study
IN atrial fibrillation The Use of
angiotensin II receptor blockers, irbesartan
As Treatment, Chronic
Is equal Than
placebo
To reduce at 4 years cardiovascular events (stroke, myocardial infarction, or death): 5.4% per years in both groups. Neither it reduced AF recurrences in patients in sinus rhythm at baseline
N Engl J Med. 2009 Apr 16;360(16):1606-17 Randomized Controlled Trial, Multicenter Study
IN atrial fibrillation, paroxysmal The Use of
angiotensin II receptor blockers (ARB), valsartan
As Prevention, Secondary
Is equal Than
placebo
To reduce recurrences of AF: 51.4% valsartan VS 52% placebo.
Eur Heart J. 2006 Aug;27(15):1841-6 Randomized Controlled Trial
IN atrial fibrillation, paroxysmal The Use of
angiotensin converting enzyme (ACE) inhibitors (perindopril) or angiotensin II receptor blockers (losartan), added to amiodarone
As Treatment, Chronic
Is better Than
amiodarone alone
To reduce, at 2 years, recurrence of AF: 19% with sartan VS 24% with ACE inhibitor VS 41% amiodarone alone.
Eur Heart J. 2003 Dec;24(23):2090-8 Randomized Controlled Trial
IN atrial fibrillation, persistent The Use of
angiotensin converting enzyme (ACE) inhibitors, enalapril, added to amiodarone
As Treatment, Chronic
Is better Than
amiodarone alone
To increase number of patients in SR at at 8 months: 84.3% enalapril VS 61.3% amiodarone alone