Atrial fibrillation: angiotensin system blockers for prevention of new-onset atrial fibrillation
DISEASE INTERVENTION COMPARISON RESULTS
J Am Coll Cardiol. 2005 Jun 7;45(11):1832-9 Meta-Analysis
IN atrial fibrillation The Use of
angiotensin converting enzyme (ACE) inhibitors or angiotensin II receptor blockers
As Prevention, Primary
Is better Than
placebo
To reduce the incidence of new onset atrial fibrillation (most cumulated studies: RRR of 28%) and reduce its recurrence after conversion (2 studies)
J Am Coll Cardiol. 2005 Mar 1;45(5):712-9 Randomized Controlled Trial, Multicenter Study
IN hypertension, primary, ventricular hypertrophy, atrial fibrillation The Use of
angiotensin II receptor blockers (losartan)
As Treatment, Chronic
Is better Than
beta-blockers
To prevent development of new-onset atrial fibrillation: AF occurred in 6.8/1,000 person-years with losartan VS 10.1 with B-blockers.