Atrial fibrillation in patients undergoing heart surgery: Amiodarone for prevention
DISEASE INTERVENTION COMPARISON RESULTS
Pharmacotherapy. 2007 Mar;27(3):360-8 Meta-Analysis
IN atrial fibrillation, postoperative, cardiac surgery The Use of
amiodarone, total doses > 3 grs, starting before or after surgery
As Prevention, Primary
Is better Than
placebo
To reduce the incidence of post-operative atrial fibrillation (OR 0.50)
Ann Intern Med. 2005 Sep 6;143(5):327-36 Meta-Analysis
IN atrial fibrillation, postoperative, cardiac surgery The Use of
antiarrhythmics, amiodarone
As Prevention, Primary
Is better Than
placebo
To decrease the incidence of atrial fibrillation or flutter (RR 0.64), ventricular arrhythmia (RR 0.42) and stroke (RR 0.39)
Eur Heart J. 2006 Jul;27(13):1584-91. Epub 2006 Jun 7 Randomized Controlled Trial
IN atrial fibrillation, postoperative, cardiac surgery The Use of
prophylaxis using antiarrhythmics, amiodarone, 600 mg oral single dose per day from Day-1 to Day7 plus IV perfusion during surgery
As Prevention, Primary
Is better Than
placebo
To reduce the incidence of post-operative AF: 34% with amiodarone VS 85% placebo. Also reduced hospitalization length of stay. Blood concentrations of amiodarone sig. differed between patients.
Cochrane Database Syst Rev. 2004 Oct 18;(4):CD003611 Systematic Review, Cochrane Review
IN atrial fibrillation, postoperative, cardiac surgery The Use of
several antiarrhythmics (amiodarone, sotalol, beta-blockers) and pacing
As Prevention, Primary
Is better Than
placebo
To reduce the incidence of atrial fibrillation (OR between 0.26 and 0.49) and possibly (non significant) reduces stroke and lenght of stay