Antiarrthythmic drugs: Amiodarone: Adverse effects
DISEASE INTERVENTION COMPARISON RESULTS
S Afr Med J. 2005 Mar;95(3):180-3 Cohorts
IN antiarrthythmic drugs, amiodarone, adverse effects, thyroid The Use of
amiodarone
As Treatment, Chronic
Is bad Than
no treatment
To develop thyroid dysfunction (either hyper or hypothyroidism): 27.6% of treated patients after a mean of 943 days of treatment VS mean 547 days in euthyroid patients.
J Am Coll Cardiol. 1997 Sep;30(3):791-8 Meta-Analysis
IN StudyID: Vorperian 1997, antiarrhythmic drugs, amiodarone, adverse effects The Use of
amiodarone, low dose maintenace
As Treatment, Chronic
Is worse Than
placebo
To produce at 12 months more side effects: thyroid OR 4,2 ; thyroid OR 4,2 ; ocular OR 3,4 ; skin OR 2,5 ; bradycardic OR 2,2 ; neurologic OR 2,0. Treatment withdrawal: 23% in amiodarone, 15% placebo