Antiarrhythmic versus antiarrhythmic: study Included in the Systematic review
DISEASE INTERVENTION COMPARISON RESULTS
Am Heart J. 2008 Jan;155(1):100-7, 107.e1 Randomized Controlled Trial
IN atrial fibrillation, paroxysmal, persistent, StudyID: PITAGORA 2008 The Use of
flecainide, or propafenone
As Treatment, Chronic
Is equal Than
amiodarone, sotalol
To modify, at 2 years, AF recurrence, mortality, adverse events
Lancet. 2012 Jul 21;380(9838):238-46 Randomized Controlled Trial
IN atrial fibrillation, persistent, StudyID: Flec-SL 2012 The Use of
flecainide
As Treatment, Chronic
Is better Than
no treatment
To reduce recurrences of AF at 4 weeks: 52% flecainide VS 70% no Tt. It seems the control group was not continued afterwards
Zhonghua Yi Xue Za Zhi. 2006 Jan 10;86(2):121-3 Randomized Controlled Trial
IN atrial fibrillation, StudyID: Niu 2006 The Use of
amiodarone
As Treatment, Chronic
Is better Than
sotalol
To reduce, at 1 year, AF recurrence, with similar number of adverse events
J Am Coll Cardiol. 2003 Jul 2;42(1):20-9 Randomized Controlled Trial
IN StudyID: AFFIRM Substudy 2003, atrial fibrillation, persistent The Use of
amiodarone
As Treatment, Chronic
Is better Than
sotalol, or a class I drug
To composite outcome (patients alive, in sinus rhythm, with no additional cardioversions and still taking the assigned drug) at 12 months: 60% amiodarone, 38% sotalol, 23% class I agents. Adverse effects were common.
Am J Cardiol. 1996 Jan 25;77(3):66A-71A Randomized Controlled Trial
IN StudyID: Aliot 1996, atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is equal Than
propafenone
To AF recurrence, proarrhythmia, adverse effects - at 12 months
Am Heart J. 2002 Jun;143(6):984-90 Randomized Controlled Trial
IN StudyID: CTAF 2000 (subordinated publication), atrial fibrillation The Use of
amiodarone
As Treatment, Chronic
Is better Than
sotalol, propafenone
To improve quality of life - at 1 year
Eur Heart J. 2002 Jul;23(13):1050-6 Randomized Controlled Trial, Multicenter Trial
IN StudyID: CTAF 2000 (subordinated publication), atrial fibrillation The Use of
amiodarone
As Treatment, Chronic
Is better Than
sotalol, propafenone
To hospital and physician costs per patient - at 12 months
Am J Cardiol. 1997 Aug 15;80(4):464-8 Randomized Controlled Trial
IN StudyID: CTAF 2000 (subordinated publication), atrial fibrillation The Use of
amiodarone
As Treatment, Chronic
Is better Than
sotalol, propafenone
To AF recurrence, adverse effects, cost, quality of life - at 12 months
N Engl J Med. 2000 Mar 30;342(13):913-20 Randomized Controlled Trial
IN StudyID: CTAF 2000, atrial fibrillation The Use of
amiodarone, low dose
As Treatment, Chronic
Is better Than
sotalol, propafenone
To AF recurrence, adverse effects - at 12 months
Eur Heart J. 1995 Dec;16(12):1943-51 Randomized Controlled Trial, Multicenter Trial
IN StudyID: FAPIS 1996 (subordinated publication), atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is equal Than
propafenone
To AF recurrence, proarrhythmia, adverse effects - at 12 months
Am J Cardiol. 1996 Jan 25;77(3):60A-65A Randomized Controlled Trial, Multicenter Trial
IN StudyID: FAPIS 1996, atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is equal Than
propafenone
To AF recurrence, proarrhythmia, adverse effects - at 12 months
J Am Coll Cardiol. 1995 Oct;26(4):852-8 Randomized Controlled Trial
IN StudyID: Hohnloser 1995, atrial fibrillation, persistent The Use of
quinidine
As Treatment, Chronic
Is equal Than
sotalol
To AF recurrence, proarrhythmia, adverse effects - at 6 months
Circulation. 1990 Dec;82(6):1932-9 Randomized Controlled Trial
IN StudyID: Juul-Moller 1990, atrial fibrillation, persistent The Use of
sotalol
As Treatment, Chronic
Is equal Than
quinidine
To AF recurrence, adverse effects - at 6 months
Z Kardiol. 1994;83(5):109-116 Randomized Controlled Trial
IN StudyID: Kalusche 1994, atrial fibrillation, persistent The Use of
amiodarone
As Treatment, Chronic
Is equal Than
quinidine + verapamil
To
Am J Cardiol. 1996 Jan 25;77(3):53A-59A Randomized Controlled Trial, Multicenter Trial
IN StudyID: Naccarelli 1996, atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is better Than
quinidine
To AF recurrence, adverse effects - at 12 months
Eur Heart J. 2001 Aug;22(16):1504-10 Randomized Controlled Trial
IN StudyID: Plewan 2001, atrial fibrillation The Use of
sotalol
As Treatment, Chronic
Is equal Than
beta-blockers, bisoprolol
To AF recurrence, pro-arrhythmia - at 12 months
Cardiovasc Drugs Ther. 1996 May;10(2):145-52 Randomized Controlled Trial
IN StudyID: PRODIS 1996, atrial fibrillation, persistent The Use of
propafenone
As Treatment, Chronic
Is better Than
disopyramide
To mortality, AFrecurrence, adverse effects, pro-arrhythmia - at 6 months
Am J Cardiol. 1993 Mar 1;71(7):558-63 Randomized Controlled Trial
IN StudyID: Reimold 1993, atrial fibrillation The Use of
propafenone
As Treatment, Chronic
Is equal Than
sotalol
To AF recurrence, adverse effects, mortality - at 12 months
Cardiologia. 1992 Feb;37(2):123-7 Randomized Controlled Trial
IN StudyID: Richiardi 1992, atrial fibrillation, paroxysmal The Use of
propafenone
As Treatment, Chronic
Is equal Than
quinidine
To AF recurrence, adverse effects - at 6 months
Arq Bras Cardiol 1998 Jan;70(1):43-9 Randomized Controlled Trial, Multicenter Trial
IN StudyID: SOCESP 1999 (subordinate publication), atrial fibrillation The Use of
sotalol
As Treatment, Chronic
Is equal Than
quinidine
To AF recurrence, pro-arrhythmia - at 6 months
Am J Cardiol. 1999 Nov 1;84(9):1033-7 Randomized Controlled Trial, Multicenter Trial
IN StudyID: SOCESP 1999, atrial fibrillation The Use of
sotalol
As Treatment, Chronic
Is equal Than
quinidine
To AF recurrence, pro-arrhythmia - at 6 months
Clin Ter. 1992 Jan; 140(1 Pt 2): 35-9 Randomized Controlled Trial
IN StudyID: Villani 1992, atrial fibrillation The Use of
amiodarone
As Treatment, Chronic
Is better Than
disopyramide
To AF recurrence, adverse effects - at 12 months
Acta Cardiologica. 1981;36(6):431-44 Clinical Trial
IN StudyID: Vitolo 1981, atrial fibrillation The Use of
amiodarone
As Treatment, Chronic
Is not available Than
quinidine
To not available