various antiarrhythmics
DISEASE INTERVENTION COMPARISON RESULTS
Am J Med. 2006 May;119(5):448.e1-19 Systematic Review
IN atrial fibrillation, rate control strategy, functional status The Use of
rhythm control strategy (various antiarrhythmics)
As Treatment, Chronic
Is better Than
rate control strategy
To to improve quatily of life: 3 of 4 RCTs found a better improvement in QoL with rate control. Not compared patients in whom SR was restored with those in persistent AF.
J Am Coll Cardiol. 2005 Nov 15;46(10):1891-9. Epub 2005 Oct 21 Randomized Controlled Trial, Multicenter Study
IN atrial fibrillation, rate control strategy, functional status The Use of
rhythm control strategy (various antiarrhythmics)
As Treatment, Chronic
Is equal Than
rate control strategy
To modify functional status of patients: modest improvement in 6-min walk distance was noted in the rhythm-control arm (about 30m) no difference appeared in dyspnea, angor or cognitive function
Pol Arch Med Wewn. 1999 May;101(5):413-8 Randomized Controlled Trial
IN StudyID: HOT-CAFE 2004 (subordinated publication), atrial fibrillation, persistent The Use of
various antiarrhythmics
As Treatment, Chronic
Is equal Than
rate control
To mortality, stroke, heart failure, AF recurrence, adverse effects - at 1 year
Kardiol Pol. 2003 Jul;59(7):1-16; discussion 15-16 Randomized Controlled Trial
IN StudyID: HOT-CAFE 2004 (subordinated publication), atrial fibrillation, persistent The Use of
various antiarrhythmics
As Treatment, Chronic
Is equal Than
rate control
To mortality, stroke, heart failure, AF recurrence, adverse effects - at 1 year