flecainide
DISEASE INTERVENTION COMPARISON RESULTS
Am Heart J. 2008 Jan;155(1):100-7, 107.e1 Randomized Controlled Trial
IN atrial fibrillation, paroxysmal, persistent, StudyID: PITAGORA 2008 The Use of
flecainide, or propafenone
As Treatment, Chronic
Is equal Than
amiodarone, sotalol
To modify, at 2 years, AF recurrence, mortality, adverse events
N Engl J Med. 2004 Dec 2;351(23):2384-91 Clinical Trial (non-controlled, non-randomized)
IN atrial fibrillation, paroxysmal, recurrent, mild or no cardiopathy The Use of
pill-in-the-pocket approach: self-administered oral loading of flecainide or propafenone
As Treatment, Chronic
Is useful Than
historical comparison
To reduce presumed AF recurrences, at 1.5 years (treatment successful in 84% of palpitations episodes), reducing emergency deparment visits, with 7% adverse events (1.5% severe)
Lancet. 2012 Jul 21;380(9838):238-46 Randomized Controlled Trial
IN atrial fibrillation, persistent, StudyID: Flec-SL 2012 The Use of
flecainide
As Treatment, Chronic
Is better Than
no treatment
To reduce recurrences of AF at 4 weeks: 52% flecainide VS 70% no Tt. It seems the control group was not continued afterwards
Am J Cardiol. 1996 Jan 25;77(3):66A-71A Randomized Controlled Trial
IN StudyID: Aliot 1996, atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is equal Than
propafenone
To AF recurrence, proarrhythmia, adverse effects - at 12 months
Am J Cardiol. 1992;70(5):11A-17A Randomized Controlled Trial
IN StudyID: Anderson 1994 (subordinate publication), atrial fibrillation, rejected The Use of
flecainide
As Treatment, Chronic
Is better Than
placebo
To AF recurrence, adverse effects - at 4 months
Circulation. 1989 Dec; 80(6): 1557-70 Randomized Controlled Trial, Multicenter Trial
IN StudyID: Anderson 1994 (subordinate publication), atrial fibrillation, rejected The Use of
flecainide
As Treatment, Chronic
Is better Than
placebo
To AF recurrence, adverse effects - at 4 months
Am J Cardiol. 1994;74(6):578-84 Cross-Over
IN StudyID: Anderson 1994, atrial fibrillation, rejected The Use of
flecainide
As Treatment, Chronic
Is better Than
placebo
To AF recurrence, adverse effects - at 4 months
Am J Cardiol. 1987 Jun 1;59(15):1337-41 Clinical Trial (non-controlled, non-randomized)
IN StudyID: Berns 1987, atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is good Than
no comparison
To AF recurrence, proarrhytmie, adverse effects - at 6 months
G Ital Cardiol. 1995 Jan;25(1):51-68 Randomized Controlled Trial
IN StudyID: Carunchio 1995, atrial fibrillation, paroxysmal The Use of
flecainide, sotalol
As Treatment, Chronic
Is better Than
placebo
To AF recurrence, adeverse effects - at 12 months
Am J Cardiol. 1992 Aug 20;70(5):44A-49A Clinical Trial (non-controlled, non-randomized)
IN StudyID: Clementy 1992, atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is - Than
no comparison
To mortality, AF recurrence, proarrhytmie, adverse effects - at 9 months
Eur Heart J. 1995 Dec;16(12):1943-51 Randomized Controlled Trial, Multicenter Trial
IN StudyID: FAPIS 1996 (subordinated publication), atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is equal Than
propafenone
To AF recurrence, proarrhythmia, adverse effects - at 12 months
Am J Cardiol. 1996 Jan 25;77(3):60A-65A Randomized Controlled Trial, Multicenter Trial
IN StudyID: FAPIS 1996, atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is equal Than
propafenone
To AF recurrence, proarrhythmia, adverse effects - at 12 months
Rev Esp Cardiol. 1998;51(Suppl 5):84 Randomized Controlled Trial
IN StudyID: Fernandez 1998, atrial fibrillation, paroxysmal The Use of
amiodarone, flecainide
As Treatment, Acute
Is - Than
propafenone
To acute revers atrial fibrillation to sinus rhythm
Am J Cardiol. 1996 Jan 25;77(3):72A-82A Clinical Trial (non-controlled, non-randomized)
IN StudyID: Hopson 1996 (former FSTS), atrial fibrillation, rejected The Use of
flecainide
As Treatment, Chronic
Is - Than
non controlled
To arrhytmia recurrence, pro-arrhytmia, adverse effects
Am Heart J. 1992 Sep;124(3):645-50 Cross-Over
IN StudyID: Lau 1992, atrial fibrillation, paroxysmal, recurrent The Use of
flecainide
As Treatment, Chronic
Is equal Than
quinidine
To AF recurrence, adverse effects - at 2 months
Cardiology. 1990;77(6):443-9 Clinical Trial (non-controlled, non-randomized)
IN StudyID: Mary-Rabine 1990, atrial fibrillation, paroxysmal, persistent, rejected The Use of
flecainide
As Treatment, Chronic
Is good Than
-
To AF recurrence, adverse effects, heart failure - at ? Months
Am J Cardiol. 1996 Jan 25;77(3):53A-59A Randomized Controlled Trial, Multicenter Trial
IN StudyID: Naccarelli 1996, atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is better Than
quinidine
To AF recurrence, adverse effects - at 12 months
Am J Cardiol. 1991 Apr 1;67(8):713-717 Randomized Controlled Trial
IN StudyID: Pietersen 1991, atrial fibrillation, paroxysmal The Use of
flecainide
As Treatment, Chronic
Is better Than
placebo
To AF recurrence, adverse effects, mortality - at 3 months
Prog Cardiovasc Dis. 2001 Sep-Oct;44(2):121-52 Meta-Analysis
IN StudyID: Slavik 2001, atrial fibrillation The Use of
IV procainamide, oral quinidine, oral flecainide, oral propafenone, IV or hight-dose oral amiodarone, IV ibutilide
As Treatment, Acute
Is better Than
placebo
To converting AF to sinus rhythm
Dtsch Med Wochenschr. 1988 Dec 2;113(48):1867-71 Randomized Controlled Trial
IN StudyID: Steinbeck 1988, atrial fibrillation, paroxysmal The Use of
flecainide, quinidine
As Treatment, Chronic
Is better Than
placebo
To AF recurrence, adverse affects - at 11 months
Circulation (Supp) 1988;78(4):ii626 Randomized Controlled Trial
IN StudyID: Van Gelder 1989 (subordinated publication), atrial fibrillation, persistent The Use of
flecainide
As Treatment, Chronic
Is better Than
placebo
To not available
Am J Cardiol. 1989 Dec 1;64(19):1317-21 Randomized Controlled Trial
IN StudyID: Van Gelder 1989, atrial fibrillation, persistent The Use of
flecainide
As Treatment, Chronic
Is better Than
placebo
To AF recurrence, adverse effects, proarrhythmia - at ? time
J Cardiovasc Pharmacol. 1989 Jan;13(1):32-6 Cross-Over
IN StudyID: Van Wijk 1989, atrial fibrillation, paroxysmal, recurrent The Use of
flecainide
As Treatment, Chronic
Is better Than
quinidine
To AF recurrence, adverse effects - at 3 months
Eur Heart J. 2003 Aug;24(15):1425-9 Randomized Controlled Trial, Multicenter Trial
IN StudyID: VERARAF 2003, atrial fibrillation, persistent The Use of
amiodarone, flecainide, verapamil
As Treatment, Chronic
Is equal Than
flecainide, verapamil addition to any of both
To AF recurrence - at 3? Month