angiotensin II receptor blockers (losartan)
DISEASE INTERVENTION COMPARISON RESULTS
Eur Heart J. 2006 Aug;27(15):1841-6 Randomized Controlled Trial
IN atrial fibrillation, paroxysmal The Use of
angiotensin converting enzyme (ACE) inhibitors (perindopril) or angiotensin II receptor blockers (losartan), added to amiodarone
As Treatment, Chronic
Is better Than
amiodarone alone
To reduce, at 2 years, recurrence of AF: 19% with sartan VS 24% with ACE inhibitor VS 41% amiodarone alone.
J Am Coll Cardiol. 2005 Mar 1;45(5):705-11 Randomized Controlled Trial, Multicenter Study
IN atrial fibrillation, persistent, hypertension, primary The Use of
angiotensin II receptor blockers (losartan)
As Treatment, Chronic
Is better Than
beta-blockers
To reduce cardiovascular events (composite of cardiovascular mortality, stroke, and myocardial infarction): 36/171 patients with losartan VS 67/171 patients with B-blokers, at aprox 4 years
J Am Coll Cardiol. 2005 Mar 1;45(5):712-9 Randomized Controlled Trial, Multicenter Study
IN hypertension, primary, ventricular hypertrophy, atrial fibrillation The Use of
angiotensin II receptor blockers (losartan)
As Treatment, Chronic
Is better Than
beta-blockers
To prevent development of new-onset atrial fibrillation: AF occurred in 6.8/1,000 person-years with losartan VS 10.1 with B-blockers.