amiodarone, sotalol
DISEASE INTERVENTION COMPARISON RESULTS
Cochrane Database Syst Rev. 2004 Oct 18;(4):CD003611 Systematic Review, Cochrane Review
IN atrial fibrillation, postoperative, cardiac surgery The Use of
several antiarrhythmics (amiodarone, sotalol, beta-blockers) and pacing
As Prevention, Primary
Is better Than
placebo
To reduce the incidence of atrial fibrillation (OR between 0.26 and 0.49) and possibly (non significant) reduces stroke and lenght of stay
Heart 2000 Sep;84(3):251-7 Randomized Controlled Trial
IN StudyID: Kochiadakis-AmSot 2000, atrial fibrillation The Use of
amiodarone, sotalol
As Treatment, Chronic
Is better Than
placebo
To AF recurrence, adverse effects - at 6 to 16 months
Am J Cardiol. 2003 Aug 15;92(4):468-72 Randomized Controlled Trial
IN StudyID: Safe-T 2005 (subordinated publication), atrial fibrillation The Use of
amiodarone, sotalol
As Treatment, Chronic
Is - Than
placebo
To AF recurrence, a number of parameters as secondary end points - at 12 to 54 months
N Engl J Med. 2005 May 5;352(18):1861-72 Randomized Controlled Trial
IN StudyID: Safe-T 2005, atrial fibrillation, persistent The Use of
amiodarone, sotalol
As Treatment, Chronic
Is better Than
placebo
To mortality, stroke, proarrhythmia, AF recurrence - at 12 months