amiodarone, low dose
DISEASE INTERVENTION COMPARISON RESULTS
Mayo Clin Proc. 2009 Mar;84(3):234-42 Meta-Analysis
IN antiarrthythmic drugs, amiodarone, clinical use, adverse effects, atrial fibrillation, persistent, rhythm control strategy The Use of
amiodarone, low dose, 100 to 200 mg/d
As Treatment, Chronic
Is better Than
placebo
To restore and keep sinus rhythm (21.3% amiodarone vs 9.2% placebo at 1 year) but increase withdrawals by side effects (10.7% per year amiodarone vs 1.9% placebo)
N Engl J Med. 2000 Mar 30;342(13):913-20 Randomized Controlled Trial
IN StudyID: CTAF 2000, atrial fibrillation The Use of
amiodarone, low dose
As Treatment, Chronic
Is better Than
sotalol, propafenone
To AF recurrence, adverse effects - at 12 months
J Am Coll Cardiol. 1997 Sep;30(3):791-8 Meta-Analysis
IN StudyID: Vorperian 1997, antiarrhythmic drugs, amiodarone, adverse effects The Use of
amiodarone, low dose maintenace
As Treatment, Chronic
Is worse Than
placebo
To produce at 12 months more side effects: thyroid OR 4,2 ; thyroid OR 4,2 ; ocular OR 3,4 ; skin OR 2,5 ; bradycardic OR 2,2 ; neurologic OR 2,0. Treatment withdrawal: 23% in amiodarone, 15% placebo