age
DISEASE INTERVENTION COMPARISON RESULTS
Stroke. 2009 Apr;40(4):1410-6 Meta-Analysis
IN atrial fibrillation, anticoagulants, vitamin K antagonists, bleeding risk, elder patients, stroke, ischemic, cerebral infarction, embolic The Use of
age
As Etiologic risk factor
Is useful Than
-
To predict an increased risk of stroke (HR per decade 1.45), major bleeding (HR per decade 1.61) and cardiovascular events (HR per decade 1.45). However the relative benefit of warfarin for preventing stroke persisted, while that of aspirin decreased
Eur Heart J. 2005 Nov;26(22):2422-34. Epub 2005 Oct 4 Descriptive, Cross-Sectional Study
IN atrial fibrillation, epidemiology The Use of
knowing actual current AF management
As Treatment, Chronic
Is useful Than
no comparison here
To consider interventions to improve adherence to guidelines, extract hypothesis to test in future randomized controlled trials
Circulation. 2007 Jun 19;115(24):3050-6 Cohorts
IN atrial fibrillation, lone The Use of
ageing, comorbidities and hypertension on the long term
As Prognostic Item
Is useful Than
-
To modulate progression and complications at 25 years: 31% developped permanent AF, stroke depended on associated risk factors, heart failure was increased, overall mortality was not increased.
Circulation. 2004 Mar 30;109(12):1509-13 Cohorts
IN atrial fibrillation, persistent, rate control strategy The Use of
warfarin use, recovering and maintaining sinus rhythm (either reciving rate or rhythm control management)
As Prognostic Item
Is better Than
not receiving warfaring or resting in atrial fibrillation
To predict a reduced mortality. However, no association of the administration of rate or rhythm control or antiarrhythmics with changes in mortality.
JAMA. 2001 Jun 13;285(22):2864-70 Cohorts
IN atrial fibrillation, stroke, ischemic, cerebral infarction, embolic The Use of
CHADS2 score: 1 point each for heart failure, hypertension, age > 75 years, and diabetes mellitus and 2 points for history of stroke or TIA
As Prognostic Item
Is better Than
other scoring systems
To predict risk of stroke: stroke rate increased by 1.5% (95% CI, 1.3-1.7) for each 1-point increase in the CHADS( 2) score from 1.9% (95% CI, 1.2-3.0) for a score of 0.
Chest. 2010 Feb;137(2):263-72 Cohorts
IN atrial fibrillation, stroke, ischemic, cerebral infarction, embolic, peripheral embolism The Use of
CHA(2)DS2-VASc score: heart failure, hypertension, age≥75 years, diabetes, previous stroke/TIA, vascular disease, age 65-74 years, sex female. 1 point each, except age>75 & previous stroke, 2 points
As Prognostic Item
Is better Than
CHADS2 and other scores
To predict risk of stroke and peripheral embolism, at 1year, specially in patients at low risk: 0% if 0 points; 0,7% if 1 point; 1.9% if 2 points; 4.7% if 3 points. Less accuracy at scores 4,5 and 6, but fewer patients classified as "intermediate risk"
BMJ. 2011 Jan 31;342:d124. doi: 10.1136/bmj.d124 Cohorts
IN atrial fibrillation, stroke, ischemic, cerebral infarction, embolic, peripheral embolism The Use of
CHA(2)DS2-VASc score: heart failure, hypertension, age≥75 years, diabetes, previous stroke/TIA, vascular disease, age 65-74 years, sex female. 1 point each, except age>75 & previous stroke, 2 points
As Prognostic Item
Is better Than
CHADS2 score
To predict risk of stroke at 1year for patients at low risk: 0.78% if 0 points; 2% if 1 point
Am Heart J. 2002 Oct;144(4):597-607 Randomized Controlled Trial
IN Study ID: AF-CHF 2008 (subordinated publication), atrial fibrillation, rate control strategy, heart failure, chronic, systolic The Use of
rhythm control: electrical cardioversion combined with antiarrhythmic drugs (amiodarone or other class III agents)
As Treatment, Chronic
Is undefined Than
rate control
To primary end point : cardiovascular mortality (protocol for a RCT)
Heart 2002 Oct;88(4):357-62 Randomized Controlled Trial
IN StudyID: GUSTO 2002, atrial fibrillation The Use of
class I agents, sotalol
As Treatment, Chronic
Is better Than
amiodarone, no treatment
To mortality at 30 days and 12 months