antiarrthythmic drugs, amiodarone, pharmacokinetics
DISEASE INTERVENTION COMPARISON RESULTS
Clin Pharmacol Ther. 2000 Jun;67(6):642-52 Cohorts
IN antiarrthythmic drugs, amiodarone, pharmacokinetics The Use of
amiodarone pharmacokinetics
As Dosage Scheme
Is useful Than
-
To help guide chronic treatment.
J Pharmacokinet Biopharm. 1999 Aug;27(4):383-96 Review (Narrative)
IN antiarrthythmic drugs, amiodarone, pharmacokinetics The Use of
new hypothesis on amiodarone pharmacokinetics
As Treatment, Acute
Is useful Than
-
To help develop new therapeutic and dosage schemes
Am J Cardiol. 1994 Oct 1;74(7):681-6 Randomized Controlled Trial
IN antiarrthythmic drugs, amiodarone, pharmacokinetics, very low dose maintenance The Use of
amiodarone, very low dose, 100 mg/d
As Treatment, Chronic
Is better Than
amiodarone 50 mg/d or placebo
To reduce, at 12 weeks, ventricular arrhythmias (total suppression in 10/14 patients amiodarone 100mg/d VS 4/15 placebo
Chin Med J (Engl). 2006 Dec 20;119(24):2030-5 Randomized Controlled Trial
IN StudyID: Jong 2006, antiarrthythmic drugs, amiodarone, pharmacokinetics, very low dose maintenance The Use of
amiodarone, very low dose, 100 mg/d
As Treatment, Chronic
Is equal Than
amiodarone, usual low dose, 200 mg/d
To maintain sinus rhythm at 5 year, after cardioversion of atrial fibrillation: 42% with 200mg/d VS 36% with 100 mg/d. Less adverse effects in the lower dose.