Thromboembolic disease: D-dimer to predict recurrence after stopping anticoagulants
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2006 Oct 26;355(17):1780-9 Randomized Controlled Trial
IN thromboembolic disease, idiopathic The Use of
D dimer, determination 1 month after stopping anticoagulation, duration of therapy
As Prognostic Item
Is useful Than
0
To decide continuation of anticoagulation: recurrences ocurred in 6.2% with normal D-dimers, 15% with elevated D-dimers not anticoagulated, 2.9% with elevated D-dimers but continuing anticoagulation
JAMA. 2003 Aug 27;290(8):1071-4 Cohorts
IN thromboembolic disease, idiopathic The Use of
D dimer, determination after 3 months of anticoagulation, duration of therapy
As Prognostic Item
Is useful Than
-
To predict long-term risk of recurrence - at 2 years: 2.35% per year if D dimers < 250 ng/L VS 5.75% per year if greater
Ann Intern Med. 2008 Oct 7;149(7):481-90, W94 Systematic Review
IN thromboembolic disease, idiopathic The Use of
D dimer, determination after 3 or more months of anticoagulation, duration of therapy
As Prognostic Item
Is useful Than
no comparison here
To predict the risk of recurrences: annual 3.5% when D-dimer normal VS 8.9% when D-dimer increased