Stroke, ischemic: Dipyridamole associated to aspirin for secondary prevention
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2008 Sep 18;359(12):1238-51 Randomized Controlled Trial, Multicenter Study
IN stroke, ischemic, cerebral infarction, thrombotic The Use of
aspirin plus extended-release dipyridamole (25 mg/200mg twice daily)
As Prevention, Secondary
Is worse Than
clopidrogel (75 mg once daily)
To reduce at 2.5 years recurrent ischemic stroke (9% aspirin VS 8.8% clopid) or cardiovascular events (13.1% both groups) and there were more haemorrhagic events (4.1% aspirin VS 3.6% clopid)
J Neurol Neurosurg Psychiatry. 2008 Nov;79(11):1218-23 Meta-Analysis
IN stroke, ischemic, transient ischemic attack, cerebral infarction, thrombotic The Use of
antiplatelet drugs, aspirin plus dipyridamole combined
As Treatment, Chronic
Is better Than
aspirin alone
To reduce recurrent stroke (HR 0.78) and cardiovascular events (HR 0.82)
Stroke. 2008 Apr;39(4):1358-63 Meta-Analysis
IN stroke, ischemic, transient ischemic attack, cerebral infarction, thrombotic The Use of
antiplatelet drugs, aspirin, dipyridamole
As Treatment, Chronic
Is better Than
aspirin alone
To reduce cardivascular events (stroke, myocardial infarction, or vascular death): RR 0.77