Renal failure, in elderly patients: creatinine based equations for estimating the glomerular filtration rate
DISEASE INTERVENTION COMPARISON RESULTS
J Am Geriatr Soc. 2009 Sep;57(9):1638-43 Diagnostic
IN kidney disease, chronic, glomerular filtration estimation, elderly patients The Use of
Cockcroft-Gault equation
As Diagnostic Tool
Is better Than
Modification of Diet in Renal Disease (MDRD) equation
To estimate measured 24-hour creatinine clearance (CrCl): Cockcroft slightly underestimates CrCl, and MDRD strongly overestimates it.
J Nephrol. 2010 May-Jun;23(3):306-13 Diagnostic
IN kidney disease, chronic, glomerular filtration estimation, elderly patients The Use of
measured 24-hour creatinine clearance, Modification of Diet in Renal Disease (MDRD) equation, Mayo Clinic quadratic equation
As Diagnostic Tool
Is bad Than
no gold standard comparison done
To accurately estimate glomerular filtration rate: values derived by MDRD and MCQ equations and CrCl significantly differed from each other in patients > 85 years.
Age Ageing. 2010 Sep;39(5):542-8 Systematic Review
IN kidney disease, chronic, glomerular filtration estimation, elderly patients The Use of
Modification of Diet in Renal Disease (MDRD) equation
As Diagnostic Tool
Is equal Than
Cockcroft-Gault equation, serum cystatin C
To accurately estimate (measured by a standard) glomerular fiiltration rate. All 3 methods better than serum creatinine alone, or than other equations.
J Am Geriatr Soc. 2003 Jul;51(7):1012-7 Diagnostic
IN kidney disease, chronic, glomerular filtration estimation, elderly patients The Use of
Modification of Diet in Renal Disease (MDRD) equation
As Diagnostic Tool
Is equal Than
Cockcroft-Gault or Baracskay equations
To accurately estimate (51Cromium-EDTA measured) glomerular filtration rate. MDRD was more accurate but Cockcroft was more precise and overall performance was similar for both
Nephron Clin Pract. 2005;101(1):c1-8 Diagnostic
IN kidney disease, chronic, glomerular filtration estimation, elderly patients The Use of
Modification of Diet in Renal Disease (MDRD) equation
As Diagnostic Tool
Is better Than
Cockcroft-Gault or Baracskay equations
To accurately estimated (inulin measured) glomerular filtration rate. All equation had low accuracy and precision and underestimated actual FGR, the MDRD the less. All did better, however, than using serum creatinine alone.