Pneumonia, community-adquired, needing hospitalization: adjunctive treatment with Cordticosteroids
DISEASE INTERVENTION COMPARISON RESULTS
Cochrane Database Syst Rev. 2017 12 13;12:CD007720 Systematic Review, Cochrane Review
IN pneumonia, community-adquired, hospitalized patients The Use of
corticosteroids
As Treatment, Acute
Is better Than
Placebo
To reduce all-cause deaths in adults with severe pneumonia (RR 0.6) and early clinical failure (RR 0.3 severe PNP, 0.7 non-severe), time to clinical cure and length of hospital stay. Hyperglycemia was more frequent (RR 1.2)
Clin Infect Dis. 2018 Jan 18;66(3):346-354 Meta-Analysis
IN pneumonia, community-adquired, hospitalized patients The Use of
corticosteroids
As Treatment, Acute
Is better Than
Placebo
To reduce time to clinical stability and length of hospital stay by approximately 1 day, but increasing hyperglycemia (22% VS 12%) and pneumonia-related rehospitalization (5% VS 3%). No effect on deaths (5% corticoids VS 6% placebo)
JAMA. 2015 Feb 17;313(7):677-86 Randomized Controlled Trial
IN pneumonia, community-adquired, hospitalized patients, treatment failure The Use of
cordticosteroids, methylprednisolone 0.5 mg/kg /12h IV
As Treatment, Acute
Is better Than
placebo
To reduce treatment failure (wide combined outcome): 13% coticosteroids VS 31% placebo. In-hospital mortality did not significantly differ: 10% corticosteroids VS 15% placebo