Pneumonia, community acquired, needing hospitalization: initial empiric antibiotic regimen with dual therapy and/or atypical pathogens coverage
DISEASE INTERVENTION COMPARISON RESULTS
Arch Intern Med. 1999 Nov 22;159(21):2562-2572 Randomized Controlled Trial
IN pneumonia, community-adquired, hospitalized patients The Use of
initial empiric antibiotic regimen with: 2nd or 3rd-generation cephalosporin plus macrolide, or a fluoroquinolone alone
As Treatment, Acute
Is better Than
non-pseudomonal 3rd-generation cephalosporin alone
To reducing mortality at 7 and 30 days
Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004418 Systematic Review, Cochrane Review
IN pneumonia, community-adquired, hospitalized patients The Use of
initial empiric antibiotic regimen with: atypical pathogens coverage
As Treatment, Acute
Is equal Than
classic only typical pathogen coverage by default
To modify mortality, clinical success rate or adverse events.
Arch Intern Med. 2005 Sep 26;165(17):1992-2000 Meta-Analysis
IN pneumonia, community-adquired, hospitalized patients The Use of
initial empiric antibiotic regimen with: atypical pathogens coverage: macrolide or quinolone
As Treatment, Acute
Is equal Than
classic only typical pathogen coverage by default: beta-lactam
To reduce mortality or adverse effects
Chest. 2003 May;123(5):1503-11 Randomized Controlled Trial
IN pneumonia, community-adquired, hospitalized patients The Use of
initial empiric antibiotic regimen with: dual therapy combining any beta-lactamic or fluoroquinolone with macrolide,
As Treatment, Acute
Is better Than
monotherapy with either antibiotic
To reducing 30-day mortality (2,5-3% intv. VS 6-12% ctrl. depending on wich monotherapy) and reducing hospital length of stay
Chest. 2007 Feb;131(2):466-73 Descriptive
IN pneumonia, community-adquired, hospitalized patients The Use of
initial empiric treatment including a macrolide
As Treatment, Acute
Is better Than
other initial antibiotics, including fluoroquinolones
To reduce, at 30 days, mortality (OR 0.61) and hospital readmission (0.59)