Pancreatitis, acute: Antibiotic prophylaxis
DISEASE INTERVENTION COMPARISON RESULTS
Am J Gastroenterol. 2008 Jan;103(1):104-10 Meta-Analysis
IN pancreatitis, acute, severe The Use of
intravenous antibiotics
As Treatment, Acute
Is equal Than
placebo
To reduce infection of pancreatic necrosis (17.8% antibiotics VS 22.9% control, non sig.) or mortality (9.3% antibiotics VS 15.2% control, non sig.)
Am J Gastroenterol. 2006 Jun;101(6):1348-53 Randomized Controlled Trial
IN pancreatitis, acute, severe The Use of
antibiotics (meropenem 500 mg t.i.d.) at admission
As Treatment, Chronic
Is better Than
antibiotics after the demonstration of necrosis at computed tomography (CT)
To reduce pancreatic infection (13.3% antibiotic at admission VS 31% antibiotic on need) and extrapancreatic infection (16.6% antibiotic at admission VS 44.8% antibiotic on need). Warning: % of pancreatic necrosis at 48H was very different between groups.