Neutropenia induced by chemotherapy: oral empirical antibiotics
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 1999 Jul 29;341(5):312-8 Randomized Controlled Trial
IN neutropenia, chemotherapy induced, febrile, empirical antibiotics The Use of
oral antibiotics, amoxicillin-clavulanate, ciprofloxacin
As Treatment, Acute
Is equal Than
intravenous antibiotics
To resolve fever and reduce mortality
N Engl J Med. 1999 Jul 29;341(5):305-11 Randomized Controlled Trial
IN neutropenia, chemotherapy induced, febrile, empirical antibiotics The Use of
oral antibiotics, amoxicillin-clavulanate, ciprofloxacin
As Treatment, Acute
Is equal Than
intravenous antibiotics
To resolve fever and reduce mortality
Cochrane Database Syst Rev. 2004 Oct 18;(4):CD003992 Systematic Review, Cochrane Review
IN neutropenia, chemotherapy induced, febrile, empirical antibiotics The Use of
oral antibiotics, quinolones alone or combined, in non severelly ill patients (not having: leukaemia, haemodynamical instability, organ failure, pneumonia, infection of a central line or a severe soft-tissue infection)
As Treatment, Acute
Is equal Than
intravenous antibiotics
To reduce mortality, treatment failure rates or adverse events
N Engl J Med. 2005 Sep 8;353(10):988-98 Randomized Controlled Trial
IN neutropenia, chemotherapy induced, non febrile The Use of
quinolones, oral levofloxacin (500 mg/d)
As Treatment, Acute
Is better Than
placebo
To reduce febrile episodes (10.8% with levofox.VS 15% with placebo), reduce hospitalizations and reduce severe infection. Death was unchanged (<1% both) Effect in long-term development of resistances unknown.
N Engl J Med. 2005 Sep 8;353(10):977-87 Randomized Controlled Trial
IN neutropenia, chemotherapy induced, non febrile The Use of
quinolones, oral levofloxacin (500 mg/d)
As Treatment, Acute
Is equal Than
placebo
To reduce febrile episodes (65% with levofox.VS 85% with placebo). Mortality and tolerability were similar in both groups. Effect in long-term development of resistances unknown.