Malaria, Plasmodium falciparum: Artesunate for acute treatment
DISEASE INTERVENTION COMPARISON RESULTS
Cochrane Database Syst Rev. 2011 Mar 16;3:CD005967 Study type to be defined
IN Condition to be defined The Use of
artesunate, intravenous or intramuscular
As Treatment, Acute
Is better Than
quinine, intravenous
To reduce death (RR 0.61) in adults and children and in different parts of the world
N Engl J Med. 1996 Jul 11;335(2):76-83 Randomized Controlled Trial
IN malaria, plasmodium falciparum, severe The Use of
artemether, artesunate, intramuscular
As Treatment, Acute
Is equal Than
quinine, intramuscular
To reduce mortality (13% artemether VS 17% quinine, p NS), reduce coma duration or reduce hospital stay.
Lancet. 2005 Aug 27-Sep 2;366(9487):717-25 Randomized Controlled Trial, Multicenter Study
IN malaria, plasmodium falciparum, severe The Use of
artesunate, intravenous (2.4 mg/kg as a bolus at 0, 12, and 24 h)
As Treatment, Acute
Is better Than
intravenous quinine (20 mg salt /kg loading dose over 4 h, then 10 mg/kg /8h over 2-8 h)
To reduce mortality (15% artesunate VS 22% quinine) while having a better tolerance (hypoglycaemia with quinidine, RR 3.2)