Hypertension, essential: Intensive blood-pressure control vs. Standard treatment
DISEASE INTERVENTION COMPARISON RESULTS
Lancet. 1998 Jun 13;351(9118):1755-62 Randomized Controlled Trial, Multicenter Study
IN hypertension, essential The Use of
intensive blood-pressure control
As Treatment, Chronic
Is better Than
standar blood-pressure control
To rate of cardiovascular events
N Engl J Med. 2015 Nov 26;373(22):2103-16 Randomized Controlled Trial, Multicenter Study
IN hypertension, essential, non-diabetic patients The Use of
intensive blood-pressure control: target SBP < 120 mmHg
As Treatment, Chronic
Is better Than
standard blood-pressure control: target SBP < 140 mmHg
To reduce cardiovascular events (1.65% per year intensive Tt VS 2.2% per year standard Tt) and all-cause mortality (HR 0.73). The reduction in cardiovascular events (including death) was more pronounced in patients > 75 years old (HR 0.67)
Cochrane Database Syst Rev. 2017 08 08;8:CD011575 Systematic Review, Cochrane Review
IN hypertension, essential, older adults The Use of
a more intensive blood-pressure control: target SBP < 140 mmHg
As Treatment, Chronic
Is better Than
usual blood-pressure control in elderly: target SBP < 150-160 mmHg
To probably (because results are not statistically significant by little) lower total cardiovascular events and all-cause mortality.