Hypertension, essential: Intensive blood-pressure control vs. Standard treatment
DISEASE INTERVENTION COMPARISON RESULTS
Cochrane Database Syst Rev. 2018 Jul;7:CD010315 Systematic Review, Cochrane Review
IN hypertension, essential The Use of
a more intensive blood-pressure control: target SBP < 135 mmHg
As Treatment, Chronic
Is equal Than
standard blood pressure targets 140 to 160 mmHg
To at 3.6 years there was no difference in total or cardiovascular mortality, nor in serious adverse events
Lancet. 1998 Jun 13;351(9118):1755-62 Randomized Controlled Trial, Multicenter Study
IN hypertension, essential The Use of
intensive blood-pressure control
As Treatment, Chronic
Is better Than
standar blood-pressure control
To rate of cardiovascular events
N Engl J Med. 2015 Nov 26;373(22):2103-16 Randomized Controlled Trial, Multicenter Study
IN hypertension, essential, non-diabetic patients The Use of
intensive blood-pressure control: target SBP < 120 mmHg
As Treatment, Chronic
Is better Than
standard blood-pressure control: target SBP < 140 mmHg
To reduce cardiovascular events (1.65% per year intensive Tt VS 2.2% per year standard Tt) and all-cause mortality (HR 0.73). The reduction in cardiovascular events (including death) was more pronounced in patients > 75 years old (HR 0.67)
Cochrane Database Syst Rev. 2017 08 08;8:CD011575 Systematic Review, Cochrane Review
IN hypertension, essential, older adults The Use of
a more intensive blood-pressure control: target SBP < 140 mmHg
As Treatment, Chronic
Is better Than
usual blood-pressure control in elderly: target SBP < 150-160 mmHg
To probably (because results are not statistically significant by little) lower total cardiovascular events and all-cause mortality.