Hepatic cirrhosis with hepatic encephalopathy: antibiotic treatment with rifaximin
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2010 Mar 25;362(12):1071-81 Randomized Controlled Trial
IN liver failure, chronic, portal hypertension, hepatic encephalopathy The Use of
minimally absorbed antibiotics, rifaximin 550 mg twice daily
As Treatment, Chronic
Is better Than
placebo
To reduce recurrence of encephalopathy at 6 months: 22% rifaximin VS 46% placebo. Similar incidence of adverse events.