HIV infection, asymptomatic: Early initiation of antiretroviral therapy at higher CD4 counts
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2010 Jul 15;363(3):257-65 Randomized Controlled Trial, Multicenter Study
IN HIV infection, initial therapy The Use of
early initiation of antiretroviral therapy at CD4+ count < 350 and > 200, in asymptomatic patients
As Treatment, Chronic
Is better Than
late intiation of therapy at CD4+ count < 200
To reduce at 21 months death (1.5% early Tt VS 5.6% late Tt) and cases of active tuberculosis (4.4% early Tt VS 8.8% late Tt)
N Engl J Med. 2009 Apr 30;360(18):1815-26 Cohorts
IN HIV infection, initial therapy The Use of
early initiation of antiretroviral therapy at CD4+ count > 350 or > 500, in asymptomatic patients
As Treatment, Chronic
Is better Than
deferred therapy until the CD4+ count fell below 350 or 500 cells/mm3
To reduce risk of death at long term (RR is the deferred group 1.69 to 1.94)