Diabetes, type 2: Intensive glucose control, as chronic treatment
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2008 Jun 12;358(24):2560-72 Randomized Controlled Trial, Multicenter Study
IN diabetes mellitus, type 2 The Use of
intensive glucose control
As Treatment, Chronic
Is equal Than
standard glucose control
To modify cardiovascular events: 18% intensive VS 20% standard. Increase of severe hypoglycaemia: 2.7% intensive VS 1.5% standard
N Engl J Med. 2009 Jan 8;360(2):129-39 Randomized Controlled Trial, Multicenter Study
IN diabetes mellitus, type 2, poor control with oral agents in monotherapy The Use of
intensive glucose control (strict glucose targets and rapid scalade in treatments)
As Treatment, Chronic
Is equal Than
standard treatment
To reduce cardiovascular events (HR 0.88). And hypoglycaemia was increased: 24% intensive VS 18% standard.
N Engl J Med. 2008 Jun 12;358(24):2545-59 Randomized Controlled Trial, Multicenter Study
IN diabetes mellitus, type 2, poor control with oral agents in monotherapy The Use of
intensive glucose control, targeting glycated hemoglobin < 6.0%
As Treatment, Chronic
Is worse Than
standard therapy, targeting glycated hemoglobin 7.0 to 7.9%
To modify, at 1 year, cardiovascular events, or overall mortality, which was increased in the intensive arm (5% intensive VS 4% standard, HR 1.22) Also intensive Tt increased hypoglycaemia: 10% VS 3.5%.