Delirium in elderly patients: use of antipsychotic drugs and increased risk of death
DISEASE INTERVENTION COMPARISON RESULTS
J Am Geriatr Soc. 2005 Oct;53(10):1658-66 Randomized Controlled Trial
IN delirium, hospitalized older patients, postoperative The Use of
antipsychotic drugs, neuroleptics, conventional, haloperidol
As Prevention, Primary
Is better Than
placebo
To reduce duration of delirium (5.4days with haloperidol VS 12 days placebo) but not to reduce frequence of developpment (15% with haloperidol VS 16.5% placebo)
N Engl J Med. 2005 Dec 1;353(22):2335-41 Cohorts
IN dementia, associated agitation or delirium The Use of
antipsychotic drugs, neuroleptics, conventional
As Treatment, Acute
Is worse Than
antipsychotic drugs, neuroleptics, atypical
To mortality: relative risk 1.37 using conventional VS atypical antipsychotics. This increased risk existed in all subgroups.
Am J Psychiatry. 2007 Oct;164(10):1568-76; quiz 1623 Cohorts
IN dementia, associated agitation or delirium The Use of
antipsychotic drugs, neuroleptics, conventional, atypicals
As Treatment, Acute
Is worse Than
psychiatric nonantipsychotic drugs
To increased mortality: 22.6%-29.1% with antipsychotics VS 14.6% with nonantipsychotics
JAMA. 2005 Oct 19;294(15):1934-43 Meta-Analysis
IN dementia, associated agitation or delirium The Use of
antipsychotic drugs, neuroleptics, atypical, olanzapine, quetiapine, risperidone
As Treatment, Chronic
Is worse Than
placebo
To mortality: 3.5% with atypical neuroleptics vs 2.3% with placebo.