Critical appraisal and Methodology: the importance of Randomization
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2000 Jun 22;342(25):1887-92 Descriptive
IN evidence based medicine, randomization The Use of
randomized controlled trials
As Methodology procedure
Is equal Than
observational studies
To get an accurate estimation real effects: average results of observational studies were remarkably similar to those of randomized controlled trials, with no systematic over-estimation
N Engl J Med. 2000 Jun 22;342(25):1878-86 Meta-Analysis
IN evidence based medicine, randomization The Use of
randomized controlled trials
As Methodology procedure
Is equal Than
observational studies
To get an accurate estimation of real effects: the estimates of the treatment effects from observational studies and randomized, controlled trials were similar (in 17 of 19 different subjects)