Chronic obstructive pulmonary disease: systemic corticosteroids for acute exacerbations
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 1999 Jun 24;340(25):1941-7 Randomized Controlled Trial, Multicenter Study
IN chronic obstructive pulmonary disease, exacerbations The Use of
systemic corticosteroids
As Treatment, Acute
Is better Than
placebo
To reduce treatment failure (death or mechanical ventilation or need to intensificate treatment): 23% with corticoids VS 33% without. Also, reduce lenght of hospital stay.
Lancet. 1999 Aug 7;354(9177):456-60 Randomized Controlled Trial
IN chronic obstructive pulmonary disease, exacerbations The Use of
systemic corticosteroids
As Treatment, Acute
Is better Than
placebo
To improve faster FEV1 and reduce lenght of hospital stay
Cochrane Database Syst Rev. 2005;(1):CD001288 Systematic Review, Cochrane Review
IN chronic obstructive pulmonary disease, exacerbations The Use of
systemic corticosteroids
As Treatment, Acute
Is better Than
placebo
To reduce, at 1 month, treatment failure (NNT 9) and improve respiratory failure and breathlessness, but increased adverse effects (OR 2.3)