Chronic obstructive pulmonary disease: non-invasive ventilation for severe exacerbations
DISEASE INTERVENTION COMPARISON RESULTS
Ann Intern Med. 2001 Apr 3;134(7):600-620 Randomized Controlled Trial
IN chronic obstructive pulmonary disease, exacerbations The Use of
bronchodilators, corticosteroids, antibiotics, and non-invasive positive-pressure ventilation
As Treatment, Acute
Is better Than
placebo or treatment not using it
To reduce death, need for intubation or reduce lenght of hospital stay.
Thorax. 2001 Sep;56(9):708-712 Randomized Controlled Trial, Multicenter Study
IN chronic obstructive pulmonary disease, exacerbations The Use of
non-invasive ventilation
As Treatment, Acute
Is better Than
standard treatment without ventilatory support
To reduce mortality: median length of survival was 17 months in those treated with ventilation VS 13 months without
Lancet. 2000 Jun 3;355(9219):1931-1935 Randomized Controlled Trial, Multicenter Study
IN chronic obstructive pulmonary disease, exacerbations The Use of
non-invasive ventilation
As Treatment, Acute
Is better Than
standard treatment without ventilatory support
To reduce need for intubation (15% with ventilation VS 27% without) and reduce mortality (10% with ventilation VS 20% without)