Atherosclerosis, coronary disease and stroke: High dose statins for secondary prevention
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2004 Apr 8;350(15):1495-504 Randomized Controlled Trial, Multicenter Study
IN coronary disease, acute coronary syndrome, high or normal cholesterol The Use of
high dose statins, atorvastatin 80 mg/d
As Treatment, Chronic
Is better Than
standard dose statins, standard lipid lowering, pravastatin 40 mg/d
To reduce cardiovascular events (composite of death from any cause, myocardial infarction, hospitalization for unstable angina, revascularization and stroke): 22,4% at 2 years in intv. VS 26,3% in ctrl.
N Engl J Med. 1999 Jul 8;341(2):70-6 Randomized Controlled Trial
IN coronary disease, stable The Use of
high dose statins, atorvastatin 80 mg/d
As Treatment, Chronic
Is better Than
routine angioplasty, without statins
To reduce cardiovascular events (composite of coronary fatal and nonfatal events and stroke) at 18 months: 13.4% statin VS 20.9% angioplasty (mostly worsening angor)
N Engl J Med. 2005 Apr 7;352(14):1425-35 Randomized Controlled Trial
IN coronary disease, stable, normal cholesterol The Use of
high dose statins, atorvastatin 80 mg/d
As Treatment, Chronic
Is better Than
standard dose statins, atorvastatin 10 mg/d
To reduce cardiovascular events (cardiac death or arrest, AMI or stroke) at 5 years: 8,7% with 80mg/d VS 10,9% with 10mg/d, an ARR of 0,44% year
N Engl J Med. 2006 Aug 10;355(6):549-59 Randomized Controlled Trial, Multicenter Study
IN stroke, normal cholesterol The Use of
high dose statins, atorvastatin 80 mg/d
As Treatment, Chronic
Is better Than
placebo
To sligthly reduce incidence of stroke (all types) at 5 years: 11.2% in statin VS 13.1% in controls. Also reduce major cardiovascular events (ARR of 3.5% at 5 years) but not to modify mortality.