Appendicitis: Antibiotics versus appendicectomy as primary acute treatment
DISEASE INTERVENTION COMPARISON RESULTS
Br J Surg. 2009 May;96(5):473-81 Randomized Controlled Trial, Multicenter Study
IN pain, abdominal, acute, appendicitis, adults The Use of
antibiotics: cefotaxime and metronidazole IV first, then ciprofloxacine and metronidazole PO
As Treatment, Acute
Is better Than
appendicectomy, open or laparoscopy
To reduce major complications: 5.4% antibiotics VS 10.8% surgery by intention to treat, 2% antibiotics VS 10% surgery per protocol. 7% of patients on antibiotics need acute surgery, and 9% had recurrence at 1 year.
Br J Surg. 1995 Feb;82(2):166-9 Randomized Controlled Trial
IN pain, abdominal, acute, appendicitis, adults The Use of
antibiotics: IV for 2 days, then PO for 10 days
As Treatment, Acute
Is better Than
appendicectomy, open or laparoscopy
To avoid surgery and complications: 1 of 20 patients on antibiotics needed acute surgery, 7 patients recurred appendicitis at 1 year.
World J Surg. 2006 Jun;30(6):1033-7 Randomized Controlled Trial
IN pain, abdominal, acute, appendicitis, non perforated, adults The Use of
antibiotics: IV for 2 days, then PO for 10 days
As Treatment, Acute
Is better Than
appendicectomy, open or laparoscopy
To reduce surgery and complications: 14% of patients on antibiotics needed acute surgery, 14% more patients had appendicitis recurrence at 1 year.