Anemia (with or without acute bleeding): Restrictive versus Liberal red-cell transfusion strategy
DISEASE INTERVENTION COMPARISON RESULTS
BMJ. 2015 Mar 24;350(350):h1354 Systematic Review
IN anemia, acute, bleeding or not The Use of
a restrictive transfusion strategy
As Treatment, Acute
Is equal Than
a liberal transfusion strategy
To modify the risk of death, overall morbidity or myocardial infarction, while using less blood cells units per patient
Ann Intern Med. 2012 Mar 26;():E-429 Consensus, Guideline
IN anemia, red blood cells transfusion The Use of
a restrictive transfusion strategy in stable patients: 7 to 8 g/dL, 8 g/dL or symptoms when preexisting cardiovascular disease. No data for acute coronary syndrom
As Treatment, Acute
Is better Than
a more liberal transfusion strategy
To use more effectively red blood cells transfusions
N Engl J Med. 2017 11 30;377(22):2133-2144 Randomized Controlled Trial, Multicenter Study
IN cardiac surgery, anemia, acute, bleeding or not The Use of
a restrictive transfusion strategy (transfuse if hemoglobin level was <7.5 g/dL)
As Treatment, Acute
Is equal Than
a liberal transfusion strategy (transfuse if hemoglobin level was <9.5 g/dL)
To modify a composite outcome (death, myocardial infarction, stroke, or new-onset renal failure with dialysis) at 28 days (11% restrictive VS 12% liberal)
N Engl J Med. 2013 Jan 3;368(1):11-21 Randomized Controlled Trial, Multicenter Study
IN gastrointestinal bleeding, upper The Use of
a restrictive transfusion strategy: when hemoglobin < 7 g/dL
As Treatment, Acute
Is better Than
a liberal transfusion strategy: when hemoglobin < 9 g/dL
To increase, at 6 weeks, survival (95% restrictive strategy VS 91% liberal) and reduce rebleeding (10% restrictive strategy VS 16% liberal)