Acute renal colic: medical therapy to facilitate the passage of ureteral calculi
DISEASE INTERVENTION COMPARISON RESULTS
Lancet. 2006 Sep 30;368(9542):1171-9 Meta-Analysis
IN urolithiasis, acute renal colic The Use of
alpha-blockers, calcium-channel blockers
As Treatment, Acute
Is better Than
placebo
To facilitate urinary stone passage: 65% (absolute risk reduction=0.31 95% CI 0.25-0.38) greater likelihood of stone passage.
Ann Emerg Med. 2007 Nov;50(5):552-63 Systematic Review
IN urolithiasis, acute renal colic The Use of
alpha-blockers, calcium-channel blockers
As Treatment, Acute
Is better Than
standard medical therapy
To improved spontaneous stone expulsion: alpha-antagonist RR 1.59 and NNT 3.3; calcium channel blocker RR 1.50 and NNT 3.9
BMJ. 2004 Jun 12;328(7453):1401 Systematic Review
IN urolithiasis, acute renal colic The Use of
non-steroidal anti-inflammatory drugs (NSAIDs) (diclofenac, ketorolac, indomethacin)
As Treatment, Acute
Is better Than
opioids (mostly pethidine)
To greater reduce pain scores, decrease probability to require rescue analgesia, reduce incidence of adverse events