bisphosphonates, zoledronate, yearly IV infusion (5 mg starting 3 months after surgery), with supplemental vitamin D and calcium
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2007 Nov 1;357(18):1799-809 Randomized Controlled Trial, Multicenter Study
IN osteoporosis, after hip fracture The Use of
bisphosphonates, zoledronate, yearly IV infusion (5 mg starting 3 months after surgery), with supplemental vitamin D and calcium
As Treatment, Chronic
Is better Than
placebo, with supplemental vitamin D and calcium
To reduce any (vertebral or not) new fracture: 8.6% in the zoledronic acid group VS 13.9% in the placebo.