bisphosphonates, zoledronate, single IV infusion (5 mg every 2 months)
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2005 Sep 1;353(9):898-908 Randomized Controlled Trial
IN Paget, bone disease The Use of
bisphosphonates, zoledronate, single IV infusion (5 mg every 2 months)
As Treatment, Acute
Is better Than
bisphosphonates, risedronate, daily oral administration for 2 months
To normalize alkaline phosphatase levels: 89% with zoledronate VS 58% with risedronate. Pain scores and quality of life improved similarly in both groups.