bisphosphonates, alendronate (10 mg daily)
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2006 Aug 17;355(7):675-84 Randomized Controlled Trial
IN osteoporosis, glucocorticoid-induced The Use of
bisphosphonates, alendronate (10 mg daily)
As Prevention, Primary
Is better Than
vitamin D, alfacalcidol (1-alfa-hidroxicoleclaciferol)
To prevent, at 18 months, new vertebral fractures (3% alendronate VS 8% alfacalcidiol) and increase bone density (+2% alendronate VS -1.9% alfacalcidol)