beta lactam monotherapy , empirical antibiotics
DISEASE INTERVENTION COMPARISON RESULTS
Cochrane Database Syst Rev. 2006;(1):CD003344 Systematic Review, Cochrane Review
IN sepsis The Use of
beta lactam monotherapy , empirical antibiotics
As Treatment, Acute
Is better Than
beta lactam plus aminoglycoside combination therapy
To improve global outcome: no differences in mortality or clinical failure, but less nephrotoxicity (RR 0.30) than aminoglycosides combination.