beta blockers, metoprolol
DISEASE INTERVENTION COMPARISON RESULTS
JAMA. 2000 Mar 8;283(10):1295-302 Randomized Controlled Trial
IN heart failure, chronic, systolic The Use of
beta blockers, metoprolol
As Treatment, Chronic
Is better Than
placebo
To reduce all-cause death or hospital admission: metoprolol 32% vs. placebo 38%
Lancet. 2008 May 31;371(9627):1839-47 Randomized Controlled Trial, Multicenter Study
IN surgical risk, major non cardiac surgery The Use of
beta blockers, metoprolol, peri-operative
As Prevention, Primary
Is worse Than
placebo
To reduce perioperative mortality (3.1% beta-blocker VS 2.3% placebo) or reduce stroke (1% beta-blocker VS 0.5% placebo), even if it reduced myocardial infarction (4.2% beta-blocker VS 5.7% placebo)