aspirin, added to vitamin K antagonists, warfarin
DISEASE INTERVENTION COMPARISON RESULTS
Arch Intern Med. 2007 Jan 22;167(2):117-24 Meta-Analysis
IN heart valve disease, mechanical heart valve, atrial fibrillation, coronary disease The Use of
aspirin, added to vitamin K antagonists, warfarin
As Treatment, Chronic
Is better Than
vitamin K antagonists, warfarin, alone
To reduce arterial thromboembolism, but only in patients with mechanical heart valve (OR 0.27) and not for coronary disease or atrial fibrillation. There was not differences in all-cause mortality and major bleeding was higher (OR 1.43)