artesunate, intravenous (2.4 mg/kg as a bolus at 0, 12, and 24 h)
DISEASE INTERVENTION COMPARISON RESULTS
Lancet. 2005 Aug 27-Sep 2;366(9487):717-25 Randomized Controlled Trial, Multicenter Study
IN malaria, plasmodium falciparum, severe The Use of
artesunate, intravenous (2.4 mg/kg as a bolus at 0, 12, and 24 h)
As Treatment, Acute
Is better Than
intravenous quinine (20 mg salt /kg loading dose over 4 h, then 10 mg/kg /8h over 2-8 h)
To reduce mortality (15% artesunate VS 22% quinine) while having a better tolerance (hypoglycaemia with quinidine, RR 3.2)