antipsychotic drugs, neuroleptics, atypical, olanzapine, quetiapine, risperidone
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 2006 Oct 12;355(15):1525-38 Randomized Controlled Trial, Multicenter Study
IN dementia, associated agitation or delirium The Use of
antipsychotic drugs, neuroleptics, atypical, olanzapine, quetiapine, risperidone
As Treatment, Chronic
Is equal Than
placebo
To improve the Clinical Global Impression of Change (CGIC) scale at 12 weeks: 32% of patients on olanzapine, 26% quetiapine, 29% risperidone, and 21% placebo (P=0.22). Time to the discontinuation of treatment for any reason was also similar.
JAMA. 2005 Oct 19;294(15):1934-43 Meta-Analysis
IN dementia, associated agitation or delirium The Use of
antipsychotic drugs, neuroleptics, atypical, olanzapine, quetiapine, risperidone
As Treatment, Chronic
Is worse Than
placebo
To mortality: 3.5% with atypical neuroleptics vs 2.3% with placebo.