antibiotic treatment
DISEASE INTERVENTION COMPARISON RESULTS
Thorax. 2008 May;63(5):415-22 Meta-Analysis
IN chronic obstructive pulmonary disease, exacerbations The Use of
short-course antibiotic treatment (5 days or less)
As Treatment, Acute
Is equal Than
longer duration of antibiotic course
To achieve clinical and bacteriological cure (OR 1.0 and 1.05 respectively)
N Engl J Med. 2018 Aug 28. doi: 10.1056/NEJMoa1808312. [Epub ahead of print] Randomized Controlled Trial, Multicenter Study
IN endocarditis, bacterial, left sided, stable The Use of
switch to oral antibiotic treatment after at least 10 days of IV antibiotics
As Treatment, Acute
Is equal Than
continuous IV antibiotic treatment for up to 6 weeks
To modify at 6 months composite of all-cause mortality, cardiac surgery, embolism or relapse: 12% with all IV Tt VS 9% with switch to oral Tt.
JAMA Pediatr. 2017 May 01;171(5):426-434 Meta-Analysis
IN pain, abdominal, acute, appendicitis, children The Use of
antibiotic treatment
As Treatment, Acute
Is equal Than
appendectomy
To obtain clinical success (91% on antibiotics). But appendicitis with appendicolith had a high failure rate: probably surgery better in this case
BMJ. 2006 Jun 10;332(7554):1355 Randomized Controlled Trial, Multicenter Study
IN pneumonia, community-adquired, hospitalized patients, duration of antibiotic treatment The Use of
discontinuing antibiotic treatment (amoxi 3 IV gr/day) after 3 days
As Treatment, Acute
Is equal Than
discontinuing antibiotic treatment after 8 days
To obtain clinical success rate at day 10 (93% both groups) and day 28 (90% stop at 3 days VS 88% stop at 10 days)