alpha-blockers, calcium-channel blockers
DISEASE INTERVENTION COMPARISON RESULTS
Lancet. 2006 Sep 30;368(9542):1171-9 Meta-Analysis
IN urolithiasis, acute renal colic The Use of
alpha-blockers, calcium-channel blockers
As Treatment, Acute
Is better Than
placebo
To facilitate urinary stone passage: 65% (absolute risk reduction=0.31 95% CI 0.25-0.38) greater likelihood of stone passage.
Ann Emerg Med. 2007 Nov;50(5):552-63 Systematic Review
IN urolithiasis, acute renal colic The Use of
alpha-blockers, calcium-channel blockers
As Treatment, Acute
Is better Than
standard medical therapy
To improved spontaneous stone expulsion: alpha-antagonist RR 1.59 and NNT 3.3; calcium channel blocker RR 1.50 and NNT 3.9