aldosterone blockers, spironolactone, added to loop diuretics and ACEI
DISEASE INTERVENTION COMPARISON RESULTS
N Engl J Med. 1999 Sept 2;341(10):709-17 Randomized Controlled Trial
IN heart failure, chronic, systolic, severe The Use of
aldosterone blockers, spironolactone, added to loop diuretics and ACEI
As Treatment, Chronic
Is better Than
placebo
To reduce overall mortality, at 2 years: 35% in intv. VS 46% in ctrl. Reduce cardiac hospitalizations and significantly improve NYHA class