adding oral hypoglycemic agents, metformin, to insulin combination
DISEASE INTERVENTION COMPARISON RESULTS
Arch Intern Med. 2009 Mar 23;169(6):616-25 Randomized Controlled Trial
IN diabetes mellitus, type 2, needing insulin The Use of
adding oral hypoglycemic agents, metformin, to insulin combination
As Treatment, Chronic
Is better Than
insulin monotherapy alone
To reduce macrovascular compications (NNT 16) but not microvascular complications.