coronary disease, stable angina
DISEASE INTERVENTION COMPARISON RESULTS
Lancet. 1992 Dec 12;340(8833):1421-5 Randomized Controlled Trial, Multicenter Study
IN coronary disease, stable angina The Use of
aspirin, low dose (75 mg/d)
As Treatment, Chronic
Is better Than
placebo
To reduce major cardiovascular events (34% relative reduction)
JAMA. 1999 May 26;281(20):1927-36 Meta-Analysis
IN coronary disease, stable angina The Use of
beta blockers
As Treatment, Chronic
Is better Than
calcium channel blockers
To reduce number of angina episodes (OR 0.31). But no significant differences in rates of death or myocardial infarction.
JAMA. 2003 Mar 5;289(9):1117-23 Randomized Controlled Trial, Multicenter Study
IN coronary disease, stable angina, elderly patients The Use of
routine invasive strategy (angiography and revascularization)
As Treatment, Chronic
Is equal Than
optimal medical therapy alone
To modify 1-year mortality (11% invasive VS 8% medical, p NS) or modify death + nonfatal infarction (17% invasive VS 20% medical). Invasive approach had increased events early months, and medical management had more cardiac events after 6 months.
Circulation. 2007 Mar 6;115(9):1082-9 Randomized Controlled Trial, Multicenter Study
IN coronary disease, stable angina, multvessel disease The Use of
coronary artery bypass graft (CABG)
As Treatment, Chronic
Is better Than
naked percutaneous coronary intervention (PCI), or medical therapy alone
To reduce, at 5 years, myocardial infarction, or refractory angina requiring revascularization (21% CABG VS 33% PCI VS 36% medical). No differences in overall mortality between the 3 goups