clostridium difficile Infecion, diarrhea, acute, infectious, antibiotic-associated
DISEASE INTERVENTION COMPARISON RESULTS
Ann Intern Med. 2012 Dec 18;157(12):878-88 Systematic Review
IN clostridium difficile Infecion, diarrhea, acute, infectious, antibiotic-associated The Use of
probiotics, mainly different types of lactobacillus
As Prevention, Primary
Is better Than
placebo
To to reduce the incidence of Clostridium difficile-associated diarrhea in patients taking antibiotics: RR 0.34
N Engl J Med. 2011 Feb 3;364(5):422-31 Randomized Controlled Trial, Multicenter Study
IN clostridium difficile infecion, diarrhea, acute, infectious, antibiotic-associated The Use of
fidaxomicin, 200 mg twice daily for 10 days, new class of narrow spectrum non-absorbable macrocyclic antibiotic
As Treatment, Acute
Is better Than
oral vancomycin, 125 mg four times daily for 10 days
To reduce recurrence rates at 4 weeks (13% fidaxo VS 24% vanco) with non-inferior rates of initial clinical response (88% fidaxo VS 86% vanco)
AHRQ Comparative Effectiveness Reviews. 2016 Mar. Report No.: 16-EHC012-EF Systematic Review
IN clostridium difficile infecion, diarrhea, acute, infectious, antibiotic-associated The Use of
high strenght: various preventive intervantions, oral vancomycine, fidaxomicin. Low strenght: probiotics, fecal transplantation
As Treatment, Acute
Is better Than
comparison
To other comparative intervantions in preventing and treating acute symptomatic c. difficile infection
CADTH Technology Report. 2011 Jan 26; No. 136, publication 2775 Systematic Review
IN clostridium difficile Infecion, diarrhea, acute, infectious, antibiotic-associated The Use of
vancomycin, oral
As Treatment, Acute
Is better Than
metronidazole, oral
To increase cure rate of initial or recurrent episodes of severe C. difficile (relative reduction 27%), while having equal effectiveness in moderate episodes.
Health Technol Assess. 2013 Dec;17(57):1-140 Randomized Controlled Trial, Multicenter Study
IN clostridium difficile infecion, diarrhea, acute, infectious, antibiotic-associated, older people The Use of
probiotics, high-dose preparation of lactobacilli and bifidobacteria
As Treatment, Acute
Is equal Than
placebo
To modify incidence of antibiotic-associated diarrhea (10% both groups), including C. difficile infections (probiotic 0.8%, placebo 1.2%, p 0.35)